Frequencies of significant comparisons ( < 0.05) for the types of gene action were: additive, 74%; dominance, 74%; additive × additive. 78%; dominant × dominant, 70%; additive × dominant, 39%; additive × additive × additive, 67%; additive × additive × dominant, 30%; ...
We report here that all three ovoD mutations are point mutations that create new in-frame methionine codons in the 5' part of ovo. There are two types of overlapping ovo transcription units, ovo alpha and ovo beta. By using various ovo-lacZ reporter genes, we determined that the long Ovo...
Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer. The mammalian Y chromosome acts as a dominant male determinant as a result of the action of a single gene, Sry, whose role in sex determination is to initi... Ryohei,Sekido,Robin,... - 《Nature》 ...
These genes are clustered at a single genomic locus in mammals and are located in humans on the q arm of chromosome 3. The new chains encoded by these genes, α4(VI), α5(VI), and α6(VI), are most similar to the α3(VI) chain. However, evidence is presented that only the α...
and eight causal variants were identified in previous analyses using the reference genome hg19 (Table2). The diseases exhibited autosomal recessive, compound heterozygous, and autosomal dominant modes of inheritance, including de novo mutations, and the causal variants included both single nucleotide and...
Heterozygous titin-truncating variants (TTNtv) in exons that are constitutively expressed in cardiac tissue have been identified as the most common genetic cause of dominant or sporadic dilated cardiomyopathy (DCM) [19, 28,29,30,31,32]. As the variants c.48396dup and c.80,539 C > T ...
The characteristics of 3D genome structure Chromatin can be divided into multilayer structures using 3D genome techniques: A/B blocks, TAD, and chromatin loops (Fig.2a). In the nucleus, chromatin can be divided into AB blocks, A block is rich in active genes and open chromatin fragments, and...
In both types multiple interacting genes are involved. For MS1 a combination of two recessive and three dominant male sterility genes is proposed, for M52 three recessives. These are minimum estimates as the exact numbers could not be determined. One of the loci for MS2 is probably linked to...
We found that both modalities clearly separated the four cell types (Fig. 1f and Extended Data Fig. 2b). To confirm accuracy, we calculated scA/B values for cell-type-specific marker genes, which showed specific enrichment in corresponding cell types (Extended Data Fig. 2c,d), consistent ...
However, the evolution of new soybean aphid biotypes capable of defeating host-plant resistance conferred by most single genes demonstrates the need for finding germplasm with multigenic resistance to the aphid. This study was conducted to map quantitative trait loci (QTL) for aphid resistance in ...