Although meta-scaffolds were more contiguous and accurate than individual sets of scaffolds, rare reference alleles should still have been retained in the meta-scaffolds. To eliminate these rare reference alleles, we aligned the three individual sets of scaffolds against the meta-scaffolds, performed v...
6Department of Biomathematics and Biostatistics, Faculty of Pharmaceutical Sciences, University of Nantes, France; 7Department of Human Genetics, Hadassah University Hospital, Jerusalem, Israel Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder characterized by hamartomas and hamartias ...
Three recessive mutagen-induced alleles that partially suppress the phenotypic expression of the semidominant powdery mildew resistance gene Mla12 have been studied. When each suppressor is present in homozygous condition, the infection type 0, conferred by gene Mla12 when homozygous, is changed to in...
strongly dominant negative alleles (G63D, R95C, G156D, G156S, E226K, G268D, G301D, G302D, Q353@, and W356@, respectively, where @ denotes a stop codon) that impair the ability of Drosophila to fly, even in the presence of a 3-fold excess of WT actin genes (antimorphic). ...
A similar situation of dominant negative effect of CALM mutations has been demonstrated for another complex CaM target, the CaMK-II, which plays as well an important role in heart physiology, and consists of 12 or 14 subunits, which interact with each other depending on the Ca2+/CaM binding ...
Trans-regulatory divergence is enriched for dominant effect, while the effects of cis-regulatory variants are additivity [6, 7]. Beneficial cis-regulatory variants are more likely to be enriched to fixation in the course of evolution, because the additive effects expose rare alleles to selection [...
The formula for parentage exclusion tates the probability ( P E ) that a given series of co-dominant alleles of known frequency should detect a falsely... A Jamieson - 《Animal Genetics》 被引量: 591发表: 1994年 Exclusion probabilities for pedigree testing farm animals These formulae can be...
number of studies. However, this hypothesis completely denies the function of dominant genes in heterosis. It is well known that heterosis doesn’t perfectly comply with heterozygosity of alleles. For instance, some rice hybrids do not perform better than their homozy...
Plasmodium falciparum accounts for up to 96% of malaria infections in this area [34], with Anopheles gambiae s.s. the dominant vector [31]. Study design and population The study conducted between 2003/05 and 2007/08 involved malaria diagnosed children (aged 1 month – 13 years) admitted in...
At 14 months of age, his EEG demonstrated 3–5 Hz multifocal spike-and-slow-wave bursts on F4–C4, F3–C3, T4–T6 areas with a background of asynchronous left- or right-dominant high-amplitude slow waves (3–5 Hz). At 16 months of age, his developmental quotient was 12 (Tsumori–...