2b), indicating the lack of structural organization before MBT. Next, we determined whether chromatin structures will emerge when rapid synchronized cell division ends by carrying out in situ Hi-C on s9 embryos. Although weak, TAD-like structures appeared across chromatin contact heatmaps (Fig. ...
Clinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are perivascular cells within the brain that are proposed as SARS-CoV-2 in
Deep networks can extract a hierarchy of robust features from the data using several layers of learning. The CNNs, which are one of the well-known classes of deep Artificial Neural Networks (ANNs) that rely on the convolution operation, has shown great success in most computer vision tasks, ...
Because the camera moves randomly in the GI tract, an anomaly may appear in some adjacent frames with different brightness, color scheme, texture, and structural form. Therefore, in practice, for sufficient assurance in diagnosis, gastroenterologists need to inspect a collection of nearby WCE frames...
The essential problem for neurobiologists is to describe the synaptic mechanisms by which neurons interacting in massive numbers create the patterns of anticipatory neural activity that control behavior. Three ...
We found that the three BPA analogues affected the transcription of more DEGs than BPA in these four classes. For example, in the lipid metabolism section, BPA down-regulated the expression of tat and ucp1, while BPM altered the expression of nocta, tat, nr1d1, hmox1a, esr2b, ucp1 ...
We demonstrate that a deep neural network can be trained to virtually refocus a two-dimensional fluorescence image onto user-defined three-dimensional (3D) surfaces within the sample. Using this method, termed Deep-Z, we imaged the neuronal activity of aCaenorhabditis elegansworm in 3D using a ...
A. When larger brains do not have more neurons: increased numbers of cells are compensated by decreased average cell size across mouse individuals. Front. Neuroanat. 9, 64 (2015). PubMed PubMed Central Google Scholar Williams, R. W. Mapping genes that modulate brain development: a ...
neurons, glias, ependymocytes, pinealocytes, pneumocytes, clara cells, goblet cells, G cells, D cells, Enterochromaffin-like cells, gastric chief cells, parietal cells, foveolar cells, K cells, D cells, I cells, goblet cells, paneth cells, enterocytes, microfold cells, hepatocytes, hepatic ...
A“conservative amino acid substitution” is one that does not substantially change the structural characteristics of the parent sequence (e.g., a replacement amino acid should not tend to break a helix that occurs in the parent sequence, or disrupt other types of secondary structure that ...