Wei et al. (2011) proposed that three major brain development processes were disrupted in autism: reduced neuron migration; an imbalance of excitatory and inhibitory synapses; and abnormal synaptogenesis. These are not regional brain disruptions, they are global disruptions. The core problem is that...
Altogether, there are ___ stages of sleep. a. two b. three c. four d. five Sleep Cycle: In order to study the sleep cycle, researchers measure the brain activity of a person as this person sleeps. It has been found that as people move through the stages of slee...
it can be argued that those methods currently being used to analyze animal social behavior create a bottleneck that significantly slows down progress in this field. Indeed, the bulk of research still relies on a small
The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase. Nature 477, 616–620 (2011). Article ADS CAS PubMed PubMed Central Google Scholar Palazzo, L. et al. Serine is the major residue for ADP-ribosylation upon DNA damage. Elife 7, e34334 (2018). Abplanalp, J. ...
The Ca2+-sensor protein calmodulin (CaM) is a major regulator of multiple cell functions. A unique and puzzling feature of human, and all so far investigated mammals, is the presence of three distinct CaM genes on different chromosomes, which code for identical proteins. How this case of appa...
"We found that CBGA was more potent than CBD in reducing seizures triggered by a febrile event in a mouse model of Dravet syndrome. Although higher doses of CBGA also had proconvulsant effects on other seizure types highlighting a limitation of this cannabis constituent. We also found CBGA to...
Results: A 15 year old boy presented with history of fever for 15 days and 2 episodes of generalized tonic,clonic seizures. He did not have any other features suggestive of connective tissue disorder.His investigations on admission revealed Hb-10.9gms/dl, Total white cell count- 5400cells/cumm...
Summed feature 8 (consisting of C18:17c and/or C18:16c), along with C16:0, were the dominant fatty acids found within the cells. Among the major polar lipids were aminolipids, glycolipids, sphingoglycolipids, phosphatidylcholine, phosphatidylglycerol, four unidentifiable lipids, glycophospholipids, ...
and requires the delivery vector to cross the blood-brain barrier (BBB). Furthermore, the brain is a more complex organ with greater complexity in cell types and significantly varying levels of gene expression between each type, making cell-specificity an additional concern in NDD therapeutics [...
LysmD3 shows an expression pattern concordant with CNS pheno- types. In early zebrafish embryos, it is expressed in the notochord, which serves both as the major skeletal European Journal of Human Genetics 1598 A novel 5q14.3-q15 microdeletion syndrome H Engels et al Table 1 Phenotype of ...