In addition, the two α-helices are in a junction position, with the α7 helix connected upstream to the long NADPH-binding loop and the α10 helix connected downstream to the C-terminal loop. These loops together form the active site and play an important role in cofactor and substrate ...
BAFF CAR-T cells were able to kill TACI or BAFF-R single knockout cells effectively, showing that either TACI or BAFF-R expression is enough for BAFF-CAR-mediated killing. Dual BAFF-R/TACI receptor knockout caused a sharp decrease in cytotoxicity compared to TACI knockout alone. This shows...
The “Tight junction” pathway tends to be upregulated in all three models, and commonly regulated proteins include several actin- and myosin-related proteins such as EZR, MYH9, MSN, ACTN1, and SLC9A3R1. These changes may act to improve cell mobility, contractility, polarity, and survival. ...
ActA and Scar1 Bind Arp2/3 at the Junction between p-40, Arp2, and Arp3 To localize the binding sites for nucleation promoting factors on Arp2/3, we carried out identical cross-linking experiments with the active fragment of hScar1 and the smallest fragment of ActA capable of stimulating...
The designed module (32 mm × 40 mm) consists of stretchable materials, including a silicone concentrator lens and a thermoplastic polyurethane sheet, and a rigid III–V triple-junction solar cell. When perfectly fitted on a 3D curved surface with a sharp curvature, a prototype module ...