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The zinc atom is coordinated by the four cysteines of the two N-terminal CXXC motifs. The zinc center of Trx2 binds zinc with a very high affinity (K[sub a] of >10[sup 18] M[sup -1]). We show that in vitro oxidation of the zinc binding cysteines by H[sub 2]O[sub 2] ...
Here, we examine the effects of arsenic, cadmium, cesium, copper, iron, mercury, nickel, and zinc on glutathione (GSH), cytoplasmic thioredoxin-1 (Trx1), and mitochondrial thioredoxin-2 (Trx2) redox states. GSH/GSSG redox states were determined by HPLC, and Trx1 and Trx2 redox states ...
(15) shows the interaction and co-localization of TBP-2 with transcriptional repressors, such as Fanconi anemia zinc finger, promyelocytic leukemia zinc finger, and histone deacetylase 1, and that the co-localization exhibited a speckled pattern in the nucleus. We also have isolated several nuclear...
Baseline serum concentrations of zinc, selenium, and prolactin in critically ill children Pediatr. Crit. Care Med., 14 (4) (2013), pp. e202-e206 View in ScopusGoogle Scholar [4] J.L. Vincent, X. Forceville Critically elucidating the role of selenium Curr. Opin. Anaesthesiol., 21 (2) ...
Detailed information on the design strategy; Importance of cysteine-rich zinc-binding sites in proteins; Factors which contribute to the the formation of a stable metal-binding site.WiszMichaelS.GarrettChristopherZ.HellingaHommeW.EBSCO_AspBiochemistry...
Collet JF, D'Souza JC, Jakob U, Bardwell JC (2003) Thioredoxin 2, an oxi- dative stress-induced protein, contains a high affinity zinc binding site. The Journal of Biological Chemistry 14, 45325-45332Collet JF, D'Souza JC, Jakob U, Bardwell JC (2003) Thioredoxin 2, an oxidative ...
Crystal structure of an unusual thioredoxin protein with a zinc finger domain. J. Biol. Chem. 2007, 282, 34945–34951. [Google Scholar] [CrossRef] Weichsel, A.; Gasdaska, J.R.; Powis, G.; Montfort, W.R. Crystal structures of reduced, oxidized, and mutated human thioredoxins: ...