The former can be dissolved together with the lipids prior to the formation of thin film, and the latter, such as oligonucleotide-based hydrophilic ingredients, can be dissolved in the hydration mediums, and then passively incorporated into liposomes via hydration procedure. Following the operation ...
One of the simplest ways to prepare liposomes in a research laboratory is the thin-film hydration method followed by extrusion. This method involves making a thin lipid film in a round-bottom flask by the removal of organic solvent. Upon the addition and agitation of the dispersion medium, het...
摘要: One of the simplest ways to prepare liposomes in a research laboratory is the thin-film hydration method followed by extrusion. This method involves making a thin lipid film in a round-bottom flask...关键词: Liposomes Thin-film hydration Extrusion Phase transition temperature Drug delivery ...
A novel method to prepare highly encapsulated interferon-α-2b containing liposomes for intramuscular sustained release A novel modified film-hydration–dilution method was employed to prepare highly encapsulated interferon-α-2b containing liposomes for intramuscular sustai... Y Li,W Yang,D Bi,... ...
Besifloxacin hydrochloride loaded liposomes were prepared by thin-film hydration technique. The effect of two independent factors (soya lecithin to cholesterol ratio and lipid to drug ratio) on characteristics of liposomes i.e. responses (entrapment efficiency, drug loading and particle size) were ...
Results revealed that formulations produced by microfluidic method had smaller, more uniform and homogenious size and zeta-potential as well as higher encapsulation efficiency when compared with liposomes manufactured by thin film hydration method. Overall, the results of this study show that carboxymethyl...
An alternative is to immobilize particles of interest by binding them to some type of support film, which—to continue using the analogy—thus serves as a slide. In this case, the goal is not only to prevent the particles of interest from diffusing into contact with the air–water interface...
Thin-film hydrationDevelopment of nanocarriers has opened new avenues for the delivery of therapeutics of various pharmacological activities with improved targeting properties and reduced side effects. Niosomes, non-ionic-based vesicles, have drawn much interest in various biomedical applications, owing to...
Hyrogenated soybean phosphatidylcholine (HSPC): Cholesterol (Chol):- 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol2000 (DSPE-PEG2000) were prepared by thin lipid film hydration followed by extrusion, as previously described52. Lipids were dissolved in a 1:1 volume ratio of chl...
Thin film hydration technique RM-loaded spanlastics are prepared by TFH [27] as per the formulation variables shown in Table2. Briefly, Span®60 or Span®80 was dissolved in 2 mL ethanol in a round-bottom flask which was then evaporated under vacuum using rotary evaporator (Rotavapor, He...