Thiazole based compounds 2a, 2b, 2f and 2i, bearing 4-bromothiophen-2-yl, naphthalen-2-yl, 2,5-difluorophenyl and 4-(trifluoromethoxy)phenyl moieties, respectively; also N-(4-acetyl-5-(naphthalen-2-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide (3b) and N-(5-(2,6-difluorophenyl...
Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents. Some of the important compounds in this class of drugs in clinical use are depicted in the following diagram. Sign in to...
anticancer, anti-inflammatory, antibacterial,antifungal, antiviral, antitubercular,antidiabetic, and antimalaria are known[31]. Thiazole ring is mostly found in microbial and marine sources and was firstly described by Hantzsch and Weber in 1887[32]. It can be found in natural products such as ...
Thiazole derivatives have been extensively studied for their antimicrobial, antiviral, and anticancer activities. They are also used as intermediates in the synthesis of various drugs and agricultural chemicals. Thiazole compounds exhibit a wide range of biological activities, making them valuable targets ...
Collectively, these results demonstrated the promising activity of the newly designed compounds as leads for subsequent development into potential anticancer agents. 展开 关键词: NSAIDs Diphenylthiazole Thiazolidinone COX Anticancer Docking DOI: 10.1016/j.bioorg.2014.10.001 被引量: 8 ...
The present invention relates to compounds of formula (I) are novel as defined herein variables. Since the compounds of formula (I) are useful as kinase inhibitors, state and proliferative disorders as well as diseases and inflammatory conditions, for example, are useful in treating cancer diseases...
Furthermore, inhibition of mutant IDH1 is expected to have little effect on non-cancerous cells, as these cells do not express the IDH1 mutation resulting in lower toxicity than typical cytotoxic anticancer agents. For these reasons mutant IDH1 inhibitors are needed as anti-cancer therapeutics. ...
Useful isothiazole derivatives as anticancer agents (57) [summary] The present invention relates to compounds of formula (1): embedded image Wherein, X R R and R is the meaning as defined herein] the salt of the compound represented by, and their pharmaceutically acceptable , a prodru... ...
Keywords: thiazoles; hydrazonoyl halides; hepatoprotective activity; anticancer activity; antimicrobial activity 1. Introduction Synthesis of novel bioactive compounds using green methods that minimize the use and generation of hazardous substances, is a major aim for many researchers. Thiazole derivatives ...
2-Aminothiazole -based compounds have been shown diverse biological activities. • Many 2-aminothiazoles are known as anticancer, antimicrobial, anticonvulsant and antidiebatic agents. • Newly identified 2-aminothiazoles in recent years and their application in medicinal chemistry are summarized in...