The main adverse effects of thiazide and thiazide-like diuretics are metabolic: hypokalemia, hyponatremia (less frequently), impaired glucose tolerance, and small increments in blood levels of low-density lipoprotein (LDL) cholesterol and triglycerides. These diuretics also elevate serum uric acid levels...
Mechanism of antihypertensive effect of thiazide diuretics. Am Heart J 1978;95:611–618.Shah S , Khatri I & Freis ED ( 1978 ). Mechanism of antihypertensive effect of thiazide diuretics . Am Heart J 95 , 611 – 618 .Shah S, Khatri I, Freis ED. Mechanism of antihypertensive effect of ...
Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells. Thiazide diuretics inhibit Na+ and stimulate Ca2+ absorption in renal distal convoluted tubules. Experiments were performed on immortalized mouse distal co... FA Gesek,PA Friedman - 《Journal of Clinical...
Mechanism of action The diuretic action of chlorothiazide, like other drugs of this series, is caused by reduced absorption of sodium and chloride ions by the kidneys during their simultaneous, intense excretion from the organism. Safety Profile Moderately_toxic by intraperitoneal and intravenous routes...
/Thiazide diuretics/|For more Mechanism of Action (Complete) data for CYCLOTHIAZIDE (7 total), please visit the HSDB record page. Antidote: Thiazide diuretic overdose should be treated by immediate evacuation of the stomach followed by supportive symptomatic treatment and monitoring of serum ...
Thiazide diuretics have long been known to function paradoxically and improve polyuria in patients with nephrogenic diabetes insipidus in whom the vasopressin V2 receptor function is absent6, although the underlying mechanism remains unestablished. Therefore, we hypothesized that thiazide diuretics may reduce...
Psychotropics, thiazide diuretics and hip fractures in the elderly. Med J Aust. 1993;158:414–7. CAS PubMed Google Scholar Pierce RO, Perry A. The effect of thiazide diuretics on bone mineral metabolism. J Nat Med Assoc. 1998;90:46–50. Google Scholar Ackerman DM, Hook JB. ...
Current concepts of pharmacotherapy in hyper- tension; thiazide-type diuretics: ongoing considerations on mechanism of action. Sica DA. Journal of Clinical Hypertension . 2004Sica DA. Current concepts of pharmacotherapy in hypertension: thiazide-type diuretics: ongoing considerations on mechanism of action...
Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells. Thiazide diuretics inhibit Na+ and stimulate Ca2+ absorption in renal distal convoluted tubules. Experiments were performed on immortalized mouse distal co... FA Gesek,PA Friedman - 《Journal of Clinical...
Mechanism of Action Na and Water Transport in the Proximal Tubule DCT diuretics are related chemically to CA inhibitors, and most retain significant CA-inhibiting potential. As discussed above, CA inhibitors interfere indirectly with the activity of NHE3 in the proximal tubule. Although this effect ...