However, drugs administered for chemotherapy have a narrow therapeutic index and therefore, there is a high incidence of unwanted side effects.聽 Thiadiazole is a five-membered ring system that has gained prominence by exhibiting a wide variety of biological activities. It has interesting聽 ...
1,3,4-Thiadiazole-Based Drugs in Clinical Use The 1,3,4-thiadiazole scaffold has wide-ranging applications as pharmaceuticals, agrochemicals, and also in material science. As pharmaceuticals, numerous drugs have been developed such as antiinflammatory, antihypertensive, anti-HIV, antidepressant, local...
分子式C2H2N2S 国际化合物标识(International Chemical Identifier,InChI)MBIZXFATKUQOOA-UHFFFAOYSA-N SMILESn1ncsc1 分子结构式 欧洲化学品管理局注册号(ECHA) 成分类型INGREDIENT SUBSTANCE / chemical 关联数据 扩展资源 Common Chemistry Inxight Drugs
CYTOTOXIC DRUGS/effectsNICOTINIC ACID/antagonistsURIC ACID/metabolismAN excessive endogenous synthesis of uric acid is present in a substantial portion of patients with gout 1 . The precise nature of the metabolic defect responsible for such excessive production is not known, but may be the result ...
Since the introduction of the first antibiotic (penicillin, 1942) into medical practice, to date, there has been an ongoing "race" between scientists creating new drugs and pathogenic bacteria. Antibiotic-bacteria are becoming progressively common, and to make matters worse, more and more bacteria ...
Large number of studies has been repoted on1,3,4- thiadiazole and their derivatives because of their wide range of biological activities. They are found to have antibacterial, anti inflammatory, anticancer, anti diabetic, anti convulsant, anti tubercular activities. Many drugs containing thiadiazole...
S Andrea,CT Supuran - 《Met Based Drugs》 被引量: 24发表: 1997年 New antiepileptic agents: structure-activity relationships (3/f)-ones, 2,5-disubstituted 1,2,4-thiadiazoles, xanthones, derivativesf isatin), enaminones, imidooxyompounds,nd valproiccid derivatives.hese newtruc... Pooja,S.,...
A new series of 2-benzyl-6-(substituted phenyl)-imidazo[2,1-b][1,3,4] thiadiazoles (S1-S8) was synthesized as potential anti-cancer agents. These compounds... SSK Ameep - 《Indian Drugs》 被引量: 0发表: 2019年 加载更多 研究点推荐 imidazo 2,1-b!- 1, 3,4!- thiadiazole compound...
1,3,6-thiadiazepines, which are a class of compounds with potential biological activities. These fused thiadiazepines, such as di[1,2,3]triazolo[1,5-a:5',1'-d][3,1,5]benzothiadiazepines, may exhibit therapeutic properties and can be further explored for the development of new drugs....
SEARCH FOR NEW DRUGS SYNTHESIS AND ANTITUMOR ACTIVITY OF NEW FURYL-2-SUBSTITUTED 1,3,4-THIADIAZOLES AND 1,2,4-TRIAZOLES[J].Pharmaceutical Chemistry Journal 2012,12(12).Hovsepyan, T.R., Grboyan, C.V., Arsenyan, F.H., and Melik-Ohanjanyan, R.G., Pharm. Chem. J. , 2012, vol. ...