The disruptors were identified as isomeric mixtures of tetrahydrofurandiols (THF-diols; 9,12-oxy-10,13-dihydroxyoctadecanoic acid and 10,13-oxy-9,12-dihydroxyoctadecanoic acid) and leukotoxindiols (LTX-diols; 9,10-dihydroxy-12-octadecenoic acid and 12,13-dihydroxy-9-octadecenoic acid). The ...
(methylene)-bis(sulfonate) to form a THF-dinitrile; and either c) oxidizing the THF-dinitrile with an acid having a pKa of ≦̸0 to generate a di-acid, or d) reducing partially the THF-dinitrile to generate a di-aldehyde, or e) reducing fully the THF-dinitrile to generate a di...
2005. Disruption of male sexual behavior in rats by tetrahy- drofurandiols (THF-diols). Steroids 70:750-754.Mani SK, Reyna AM, Alejandro MA, Crowley J, Markaverich BM. Disruption of male sexual behavior in rats by tetrahydrofurandiols (THF- diols). Steroids 70: 750 -754, 2005....
Owing to the prevalence of this structural motif in biologically active natural and non-natural compounds, a number of methods for the stereoselective synthesis of THF-diols have been developed. Strategically, the stereochemistry is often established in an initial chemical transformation (e.g. by ...
In general, the process involves: a) generating a tetrahydrofuran-2,5-diyl-bis(methylene)-bis(sulfonate) from bHMTHFs using a sulfonate; b) displacing nucleophilically at least a sulfonate leaving group from the tetrahydrofuran-2,5-diyl-bis(methylene)-bis(sulfonate) to form a THF-dinitrile; ...
ChemInform Abstract: A Double Donor-Activated Ruthenium(VII) Catalyst: Synthesis of Enantiomerically Pure THF-Diols.furan derivativesdiastereoselective synthesesenantioselective syntheses (incl. cis/trans-isomerism)catalysisphase-transfer catalysisring closure reactionsChemInform is a weekly Abstracting Service, ...
Diols of formula (I) are new; In (I) A is tetramethylene gp., opt. substd. with up to two 1-4C alkyl gps.; B1, B2 is 1-10C hydrocarbylene, opt. contg. in-chain ether-O; R1 is H or 1-10C hydrocarbyl; X is a gp. of formula -SiR2R3-(-O-SiR2R3)p- (with R2, ...
In this work, we studied the chain dimensions, shape, and thermodynamic characteristics of poly(蔚-caprolactone) diols (HO-PCL-OH) in solution. PCL diol samples of different molecular weights and architectures were synthesized using immobilized Yarrowia lipolytica lipase as catalyst. Gel permeation ...
Piccialli, V.; D'Errico, S.; Borbone, N.; Oliviero, G.; Centore, R.; Zaccaria, S. A general synthesis of bis-α-acyloxy-1,4- and -1,5-diketones through catalytic oxidative opening of acylated THF and THP diols. Eur. J. Org. Chem. 2013, 2013, 1781-1789. [CrossRef]...
l-Serine methyl ester hydrochloride was converted to (S)-2-[N-(benzyloxycarbonyl)amino]-3-(tert-butyldimethylsiloxy)propanal (6). Homocoupling of 6 promoted by [V2Cl3(THF)6]2[Zn2Cl6] (1) gave C2-symmetric diol (7). After manipulation of ... Min,Kang,Jeonghan,... - 《Journal...