CAR-T cell therapy in solid tumors: applications, challenges and recent advances In recent years, T cells engineered with CAR demonstrated promising outcomes against B cell leukemia and lymphoma, proving its therapeutic anti-cancer potential [36]. Indeed, two CAR-T cell therapies Tisagenlecleucel ...
Phosphodiesterases (PDEs) have become a promising therapeutic target for various disorders. PDEs are a vast and diversified family of enzymes that degrade cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which have several biochemical and physiological functions. Phosphodieste...
Statistical analyses were performed using IBM SPSS Statistics 23 (Armonk, New York) and the graphs were generated with GraphPad Prism 7 (San Diego, California). The data were assessed for normality using a Q-Q plot and Shapiro-Wilk test, and were found to follow a non-Gaussian distribution....
Then, samples were dehydrated in increasing ethanol solutions (in accordance with the standard procedures). Coverslips with cells were then inverted (with the cells facing downwards) and placed on top of BEEM® capsules filled with Spurr resin (Electron Microscopy Sciences, Hatfield, PA, USA). ...
To morphologically evaluate the gastrocnemius and quadriceps muscles, H/E stained muscle sections were visualized by optical microscopy (Olympus BX63; Olympus Life Science Solutions, Center Valley, PA (n = 6 SMA-EVs; 5 SMA-PBS; 6 WT): to measure the mean fibers area and Feret’s max ...
Glaucoma Medical Therapy,:edited by Peter A. Netland and Robert C. Allen, San Francisco, The Foundation of the American Academy of Ophthalmology, 1999, 270 pages, illus. Member Price: $70.00. Non-member Price: $100.00doi:10.1016/S0039-6257(00)00160-0Angelo...
Groups and conditions for performing antimicrobial photodynamic therapy.Ludmila, Matos BaltazarAimee, E. KrauszAna, Camila Oliveira SouzaBrandon, L. AdlerAngelo, LandriscinaTagai, MusaevJoshua, D. NosanchukAdam, J. Friedman
F. SanvitoC. BrombinC. Di SerioA. D'AngeloM. ChuahBloodCantore A, Nair N, Della Valle P, Di Matteo M, Matrai J, Sanvito F, et al. Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice . Blood (2012) 120 :4517–2010.1182/blood-2012-05-...
Future research in the field should focus on improving prediction of weight gain risk after BC, as well as integrating biological data, on patients’ stratification on the basis of adoption of weight loss interventions and on improving integration of digital solutions to deliver them and promote sus...
To morphologically evaluate the gastrocnemius and quadriceps muscles, H/E stained muscle sections were visualized by optical microscopy (Olympus BX63; Olympus Life Science Solutions, Center Valley, PA (n = 6 SMA-EVs; 5 SMA-PBS; 6 WT): to measure the mean fibers area and Feret’s max ...