Paul Ehrlich first proposed the concept of targeted therapy in the 1890s as a “magic bullet” that would be completely specific for the target and thus safe without any additional toxicity14,16. This theory was initially applied to infectious diseases but not to anticancer therapy due to insuff...
The discovery of the Cystic fibrosis (CF) gene in 1989 has paved the way for incredible progress in treating the disease such that the mean survival age of individuals living with CF is now ~58 years in Canada. Recent developments in gene targeti
Here, we review the progress made in the development of CRISPR systems as a tool to study cancer, and the emerging adaptation of these technologies to improve diagnosis and treatment.This is a preview of subscription content, access via your institution ...
W. Y. Gene therapy for neurological disorders: progress and prospects. Nat. Rev. Drug Discov. 17, 641–659 (2018). This is an up-to-date review on the current trends and challenges for AAV-based CNS gene therapy. CAS PubMed Google Scholar Petit, L., Khanna, H. & Punzo, C. ...
Template A review should describe an overview of recent progress in important fields of research, providing an appreciation of the significance of the work, and an outlook into potential future directions. Unstructured abstract ≤ 300 words
progress that has been made to date using patient-derived neurons to recapitulate key aspects of AD pathology and how these models have contributed to a deeper understanding of AD molecular mechanisms, as well as addressing the key challenges posed by using this technology and what progress is ...
Clinical core of the Alzheimer’s Disease Neuroimaging Initiative: progress and plans. Alzheimers Dement. 2010;6(3):239–46. Article Google Scholar Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004;256(3):183–94. Article CAS Google Scholar Jack CR Jr, ...
For the past 2 decades, key progress on medicinal chemistry approaches contributed to a brisk and intriguing development of promising new classes of druggable moieties that showed renin inhibition. Chemically diverse molecules expanded the horizon to achieve the target. Molecules that resembled the transi...
impressive and give a reason to hope for further progress. Of special interest is the rapid development of genome-editing systems, particularlyClustered regularly interspaced short palindromic repeats (CRISPR) / CRISPR-associated protein (Cas), which make it possible to precisely repair unwanted ...
RNA therapy refers to the treatment or prevention of diseases using RNA-based molecules. The recent advent of a series of effective messenger RNA-based vaccines in response to the COVID-19 pandemic has reignited research interest in RNA therapy. Based on