The libraries were indexed using a Chromium i7 Sample Index Kit, pooled and sequenced on NovaSeq 6000 System (Illumina) by Novogene. Raw sequencing data were processed using the Cell Ranger software version 6.0.0 or higher (10X Genomics). Sequencer’s base call files (BCLs) were demultiplexed...
The last 3 years have seen the emergence of promising targeted therapies for the treatment of hepatocellular carcinoma (HCC). Sorafenib has been the mainstay of treatment for a decade and newer modalities were ineffective and did not confer any increased
Intravenous immunoglobulin (IVIG) contains immunoglobulin G of all subclasses obtained from pooled human plasma [77]. IVIG has been used to provide immunity to viral infections [78], including SARS, although the benefits of the treatment were inconclusive and some cases of thromboembolic complications...
progression [10]. Similarly, more than 30% non-small cell lung cancer (NSCLC) patients were found to have relapsed after an objective initial response to nivolumab at the 2-year follow-up [11]. Accordingly, the pooled analysis of four clinical trials of nivolumab in NSCLC patients revealed ...
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Centralised and decentralised facilities have differing labour requirements with the latter risking production if the skilled labour pool is weak. Managing talent across national boundaries may be challenging to administer (4). Another barrier for large scale manufacture of CGTs is the high cost of ...
On the day of vaccination, each pool of NEO-PV-01 was mixed with the adjuvant polyinosinic polycytidylic acid polylysine carboxymethylcellulose (poly ICLC; Hiltonol®) for a concentration of 300 μg/mL of each peptide. Each patient was scheduled to receive 5 doses of vaccination during the...
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In a second test, mice were clocked on how long they actively tried to escape a pool of water. Those exposed to night lights stopped struggling and just floated in the water, a sign of “behavioral despair”, 10 times as long as the mice that had experienced normal nighttime darkness. ...
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