Introduction: Hearing loss is the most common sensory deficit in humans, and roughly half of childhood-onset sensorineural hearing loss is genetic. Advances in gene therapy techniques have led to the first clinical trials for OTOF-associated hearing loss DFNB9. Therapies for other hearing loss ...
Hearing loss grades and the International classification of functioning, disability and health. Bulletin of the World Health Organization. 2019;97(10):725. 3. Ahmed H, Shubina-Oleinik O, Holt JR. Emerging gene therapies for genetic hearing loss. Journal of the Association for Research in ...
近日,复旦大学附属眼耳鼻喉科医院舒易来教授团队在美国细胞与基因治疗学会会刊Molecular Therapy上发表了题为:Advances in gene therapy hold promise for treating hereditary hearing loss的综述论文 该论文系统、全面论述了遗传性耳聋的分类及细胞学机制,并重点阐述了三种主要的基因治疗策略在遗传性耳聋临床前试验中的成功...
Limited capacity for hair cell regeneration in mammals Mammalian auditory hair cells do not spontaneously regenerate, unlike hair cells in lower vertebrates, and, as a result, hearing loss due to the loss of hair cells is permanent and intractable. Although recent mouse studies showed limited regene...
Because of the serious trend of youthful hearing loss, people are paying more and more attention to hearing protection. However, due to the need for work and study, it is difficult to completely eliminate the use of headphones. Therefore, there are a large number of artic...
Gene therapy for HHL Gene therapy is expected to be a powerful tool for restoring natural hearing function by targeting defective deafness genes. There are primarily three strategies to perform gene therapy: gene replacement, gene suppression, and gene editing (Figure 3A). Importantly, different stra...
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Patients treated with cranial radiation therapy (RT) are at risk for sensorineural hearing loss (SNHL). Although SNHL is often characterized as a delayed consequence of anticancer therapy, longitudinal reports of SNHL in childhood cancer survivors treated with contemporary RT are limited. We report...
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At East Coast Audiology & Physical Therapy, we have been serving the community for over 20 years. We are proud to offer top-quality audiology and physical therapy services to patients on the East Coast. Our team of experienced professionals is committed to providing compassionate care to each an...