The androgen receptor (AR) is central to the initiation and growth of prostate cancer and to the therapeutic response to hormones. Although it has been known for many years that the expression and activity of AR is controlled by AR coregulators, the manipulation of endogenous AR coregulators ...
Immune-based Therapies. Current clinical trialsOur Therapies What brings you here? "I am apatientfighting prostate cancer." MVI's immunotherapies are changing the trajectory of PSA and delaying disease progression. Learn more "I am aclinicianlooking for new therapies." ...
Fred Saad, CQ, MD, FRCS, FCAHS, discusses how combining therapies like androgen receptor–targeted agents, androgen deprivation therapy, and docetaxel can potentially improve outcomes for metastatic prostate cancer patients, with treatment selection influenced by factors such as disease volume and risk ...
Prostate cancer is a leading cause of cancer morbidity and mortality in the United States. Animal and clinical studies performed four decades ago suggested that immunological approaches might be useful for the treatment of prostate cancer. The wealth of information that has been learned over the last...
Current FDA approvals of 2 PARP inhibitors, olaparib (Lynparza; AstraZeneca) and rucaparib (Rubraca; Clovis Oncology), based on the PROFOUND (NCT02987543) and TRITON2 (NCT02952534) trials, respectively, have provided a new therapeutic option for prostate cancer patients with BRCA mutations.3,...
摘要: Universal agreement has not been reached as to the best treatment for cancer of the prostate (CaP) at any stage. Radical prostatectomy, external-beam radiation therapy, and brachytherapy are potentialDOI: 10.1007/978-1-84628-738-1_32 年份: 2008 ...
Despite its prominence as the most frequently diagnosed solid tumor among men in the United States, relatively little is known about the etiology of prostate cancer. Furthermore, research into treatment strategies for prostate cancer continues to lag behind research for the other most common cancers....
Emerging novel therapies for advanced prostate cancer. This review examines the development and efficacy of novel treatment options for advanced prostate cancer and discusses novel therapies that are on the hor... S Osanto,H Van Poppel - 《Therapeutic Advances in Urology》 被引量: 90发表: 2012年...
Soil samples amended with wheat straw (0%, 0.1% and 0.2%) and (15NH4)2SO4 (200mg Nkg–1 soil, 2.213 atom% 15N excess) were incubated at 302C for 20 days with or without the arrangement for trapping CO2 resulting from the decomposition of organic matter. Nitrification (as ...
Despite its prominence as the most frequently diagnosed solid tumor among men in the United States, relatively little is known about the etiology of prostate cancer. Furthermore, research into treatment strategies for prostate cancer continues to lag behind research for the other most common cancers....