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Pharmacological profiles of animal- and nonanimal-derived sulfated polysaccharides – comparison of unfractionated heparin, the semisynthetic glucan sulfat... Sulfated polysaccharides (SP) such as heparin are known to exhibit a wide range of biological activities, e.g., anticoagulant, anti-inflammatory,...
Experimental and Clinical Therapeutic Uses of Low-Molecular-Weight Heparin / Protamine Micro / Nanoparticles We also reported that LMW-H/P M/NPs bind to cell surfaces of adipose-derived stromal cells (ASCs) through specific interactions between LMW-H/P M/NPs and cell surface heparin-binding pr...
Although the pathophysiological mechanisms remain elusive, accumulating experimental and clinical data are showing that anticoagulants, particularly low molecular weight heparin, may have an important role as anticancer agents. Although this concept was first introduced decades ago, advancement in research has...
The present invention relates generally to small peptide-based constructs, including derivatized constructs, and their therapeutic uses. The constructs and derivatized constructs can have at least one of heparin binding, heparin neutrali... Roger G. Little II,JJ Lin,JGK Gikonyo - US 被引量: 11...
This exploratory study of a multiplatform randomized trial investigating the effects of therapeutic-dose heparin in early-pandemic hospitalized COVID-19
Six weeks after injury, 1000 I.U. heparin (David Bull Laboratories, Mulgrave, Victoria) in 1 ml saline were injected into an ear vein of each rabbit. Five minutes later, the rabbits were euthanased with an overdose of pentobarbitone (325 mg/ml Lethabarb, (Virbac Australia Pty Ltd, Victo...
This randomized clinical trial evaluates the effects of therapeutic-dose low-molecular-weight heparin vs standard prophylactic or intermediate-dose
Induction of fibroblast and keratinocyte migration by angiotensin II via heparin-binding epidermal growth factor (EGF)-like growth factor-mediated EGF receptor transactivation. J. Biol. Chem. 281, 13209–13216 (2006). Article CAS PubMed Google Scholar Lewis, R. J. et al. Rationale and design...
6.2. Therapeutic uses of phage in the lungs Perhaps the earliest reported use of phages against in the lung may be in a 1936 case where infection by a “colon bacillus” was treated by directly applying a “colon lytic filtrate” to the infected area [204]. Notably in this case, the pa...