where it acts to regulate cell growth, differentiation, metabolism and death, and is frequently dysregulated in many human cancers [1]. It is the prototype member of the Myc family that also encompasses N-Myc and L-Myc proteins
Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Mycdoi:10.1186/S12943-020-01291-6Sarah MaddenAline Dantas De AraujoMara GerhardtJody MasonBioMed Central
4.1. Using nano-delivery systems containing compounds that inhibit P-gp Recently, the use of nanotechnology has been suggested to have the potential to improve and increase the detection and treatment of cancer by specifically delivering drugs to cancerous cells/sites (Sutradhar and Amin, 2014). ...
Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment Go J. Yoshida Journal of Hematology & Oncology volume 10, Article number: 67 (2017) Cite this article 16k Accesses 189 Citations 1 Altmetric Metrics details Abstract...
RAS genes are the most commonly mutated oncogenes in cancer, but effective therapeutic strategies to target RAS-mutant cancers have proved elusive. A key aspect of this challenge is the fact that direct inhibition of RAS proteins has proved difficult, leading researchers to test numerous alternative...
Several approaches have attempted to inhibit MYC directly or indirectly at all levels of its regulation. Some strategies that have shown promising results in vivo have focused on preventing MYC gene expression using antisense oligonucleotides (ASOs) that target MYC mRNA14 or G4-quadruplex binders that...
patients still benefit little due to the short therapeutic window and the risk of ischemia/reperfusion injury. It is therefore urgent to figure out the neuronal death mechanisms following ischemic stroke in order to develop new neuroprotective strategies. Regarding the pathogenesis, multiple pathological ...
to inhibit hydroperoxide-induced ferroptosis.45In 2019, CD8+T cells were shown to induce tumor ferroptosis during cancer immunotherapy.19In the meantime, E-cadherin-mediated intercellular contacts control ferroptosis sensitivity through the Merlin/Hippo/Yes-associated protein 1(YAP) pathway to regulate ...
Diverse screening strategies, including fluorescence resonance energy transfer, fluorescence polarization, two hybrid and protein complementation assays have identified several lead compounds that inhibit Myc-Max dimerization and one compound that stabilizes the Max homodimer. Representative compounds interfere ...
Urological cancers have been responsible for high mortality and morbidity worldwide, and developing new strategies in their treatment, especially based on gene therapy, is of importance since these malignant diseases do not respond to conventional therapies. In the current review, three important aims ...