1. A method comprising: obtaining a bodily fluid from a subject having a level of disease mediators (y); contacting the bodily fluid with an adsorbent material consisting essentially of a synthetic carbon particle (SCP) to produce a first filtrate; contacting the first filtrate with an adsorbent...
More importantly, therapeutic effects of REG1 can be controlled by dosage of RB007 and it is less toxic than heparin/protamine, which is also an anticoagulation/antidote pair currently available [74]. Phase II clinical trials for using REG1 in percutaneous coronary intervention for patients with ...
(DAMP) molecules also known as alarmins and may include intracellular proteins, like heat-shock proteins, high-mobility group box 1 (HMGB1) and proinflammatory S100 proteins linked to inflammation and cancer [16] or non-protein molecules like ATP [17], uric acid [18], heparin sulfate and ...
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cells Review Fibroblast Growth Factor Receptor 4 Targeting in Cancer: New Insights into Mechanisms and Therapeutic Strategies † Liwei Lang 1 and Yong Teng 1,2,3,* 1 Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA; ...
In detail, the multimeric design provides NT4 with the ability to bind heparin and receptors belonging to the low density lipoprotein receptor (LDLR) family, which is well known to have a role in cancer biology [48]. Systematically modifying the neurotensin sequence in NT4 peptides led to the...