59 A case report demonstrated that untreated periodontitis may progress to septicemia and result in septic cavernous sinus thrombosis and PE due to sustained prothrombotic status, ultimately increasing the risk of developing VTE episodes considerably.126 A study of bacterial signatures in thrombus as...
we provide in vivo evidence of the potential for RDV to treat MERS-CoV infections. Efficacy testing of antiviral regimens in humans like those in the MIRACLE trial are essential to progress antiviral development and prioritize therapies most likely to improve clinical outcomes in MERS-CoV patients....
65,66]. These biological agents can directly assail and remove malignant cells or serve as a strategy to enhance the efficacy of additional pharmaceuticals in cancer therapy [67,68]. Oncolytic bacteria
Although some of these assumed magico-fantastic healing properties of insects and other invertebrates in the examples given above and wormy creatures used in easing pain stemming from a tooth cavity as well as the consumption of stick insects to lose (and that of fat termite queens to gain) wei...
Despite progress in diagnosis and treatment of PDAC, the post-operative 5-year survival rate remains low. Indeed, most patients at the time of diagnosis present with distant metastasis or life-threatening complications derived from the disease1. The promise of personalised medicine, which has ...
Furthermore, in recent years, due to the unique properties of nanomaterials in terms of size, surface and capacity, considerable progress has been made in nanotechnology-based theranostic strategies for cancer treatment as vehicles for the delivery of anti-angiogenic agents [78]. Some examples of ...
Firstly, this limits progress to organisms and life stages that can be isolated and cultured; secondly it relies on applicable compounds having been found in related or- ganisms; and thirdly it limits discovery as it looks at one target at a time for feasibility. In silico drug target discov...
Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society. However, the relatively few currently approved drugs for these
In this review, we aim to discuss the possible technologies that have been explored for the development of LAIs containing hydrophilic small molecules or proteins along with the examples of the approved formulation. Lastly, the release mechanism from different systems have also been discussed in brief...
Biological aspects in controlling angiogenesis: current progress. Cell Mol Life Sci. 2022;79:349. Article CAS PubMed PubMed Central Google Scholar Raza A, Franklin MJ, Dudek AZ. Pericytes and vessel maturation during tumor angiogenesis and metastasis. Am J Hematol. 2010;85:593–8. Article ...