After phase I study of presurgical evaluation for intractable epilepsies, some patients are thought likely to have an uncertain epileptogenic focus. These patients require intracranial electrodes (phase II study) to localize the focus before possible therapeutic procedures. The diagnostic neurosurgical ...
but for these drugs such monitoring is essential in order to achieve maximum efficacy of the drug as well as to avoiddrug toxicity. Therapeutic drug monitoring is also useful in avoidingadverse drug events. Currently, the old approach of therapeutic drug monitoring for avoiding drug toxicity...
Following the detection of non-optimal drug concentrations, different procedures for dose adjustments are possible: in the simplest case, oncologists will use the drug label, dosing algorithms or nomograms to determine a new dose [27]. Although simple, this approach requires to abide with the ...
The EPM was performed according to previously described procedures50,86,87 using a mouse EPM (model ENV-560A) purchased from Med Associates (St. Albans, VT). All four arms are elevated 1 meter from the floor, with the drop-off detectable only in the open arms. The EPM contained two ope...
The use of a biomaterial approach would allow controlling drug release in a more accurate and sustained manner, without unwanted side effects stemming from the need for higher doses, multiple injections, and invasive procedures for implant placement [97]. Beyond the BBB, it is more possible for...
Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006; 1: 848–858. 40 Janus C. Search strategies used by APP transgenic mice during navigation in the Morris water maze. Learn Mem 2004; 11: 337–346. 41 Garthe A, Behr J, Kemper...
Table 1 Primer sequences for qPCR Full size table Neuroethological score The neurobehavioral changes in the different groups at 1-day postoperation were evaluated by the neuroethological scores [15], according to the following procedures and criteria: (1) The corneal reflex was tested by gently...
The diagnostic procedures andtherapeutic managementof the mother with possiblehyperthyroidismpresent some hazards to the breastfed infant. The diagnosis can be made without radioactive material. The combination of an elevated serum T4level and a normal resintriiodothyronine(T3) uptake is helpful. These ...
survival could be increased from 33 to 49 weeks in the group treated with hyperthermia, and overall survival could be extended 9 weeks by application of hyperthermia; 2-year survival rates were 0% and 10% for the two groups, respectively. However, technical setup and treatment procedures were ...
It will be appreciated that where the active moiety is transformed by the separation procedures described above, a further step may be required to convert the transformation product back to the active moiety. Certain compounds of formula I or II may exist in different tautomeric forms or as diffe...