Ugalde-Triviño L, Díaz-Guerra M (2021) PSD-95: an effective target for stroke therapy using neuroprotective peptides. Int J Mol Sci 22(22):12585 PubMed PubMed Central Google Scholar van der Most PJ et al (
Cancer vaccines are a growing field of research in OC. Peptide-based vaccines consist of known or predicted tumor-associated antigens (TAAs) administered with adjuvants to enhance immunogenicity. Presentation of processed antigens by antigen presenting cells and dendritic cells (DC) leads to activatio...
Longitudinal bio-banking data collection could help to analyse the effect of TPE on host immune responses. Regarding the simultaneous removal of circulating biomarkers, alternative tools to assess resolution of infection are needed along with such TPE-driven changes in humoral inflammatory parameters (suc...
Stable antibody expression at therapeutic levels using the 2A peptide. Nat Biotechnol. 2005;23(5):584–90. doi:10.1038/nbt1087. (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new window)Google Scholar...
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Cytokines are small molecule peptides, proteins, or glycoproteins synthesized and secreted by various cells102. By binding to receptors on target cell membranes, cytokines transmit signals into the cell’s interior, orchestrating numerous kinds of biological functions, including immune modulation, inflammat...
and the specific USP11 inhibitors remain to be further investigated and developed. Targeting the catalytic structural domain of USP11 is the main target for the design of specific USP11 inhibitory molecules. Regardless, USP11 may be a potentially beneficial therapeutic target for cancer therapy and ...
Scientists are trying hard to develop new potential therapeutic strategies, consisting of monoclonal antibodies, vaccines, peptides, Interferon-based therapies, protease inhibitors, and small-molecule drugs to defeat the COVID-19 pandemic. However, it might take several months to test their efficacy in...
[74]. Paclitaxel, a chemotherapeutic agent, induces cleavage of lamin A/C, enhanced by the synthetic peptides Smac/DIABLO [75]. It should be noted that HGPS is characterized by a large increase in the rate of apoptosis [63], and while application of apoptosis inducers in HGPS treatment is...
The peptides were separated by applying a linear gradient of acetonitrile in 0.1% formic acid (5–35%) for 2 h, at a flow rate of 300 nL/min. The Q- Exactive was operated in data-dependent mode defined to analyze the ten most intense ions of MS analysis (Top 10). The MS ...