considered during implementation.This plenary talk will provide an overview of what is currently known about promising program models in therapeutic residential care (TRC) and the implementation of client-specific psychosocial interventions that are supported by research and are relevant for youth in TRC...
THE THERAPEUTIC COMMUNITY METHOD IN PSYCHIATRIC AND GERIATRIC CARE: AN OVERVIEW The purpose of this paper is to report on the history, current everyday work and research, and some future perspectives of the therapeutic community (TC) movement and models. Also some practical Finnish experiences are...
The aims of this study were to determine whether GM-CSF controls inflammatory and/or arthritic pain.A model of inflammatory pain (complete Freund's adjuvant footpad), as well as two inflammatory arthritis models, were induced in GM-CSF(-/-) mice and development of pain (assessment of weight...
hyperlipidemia, obesity and non-alcoholic fatty liver disease (NAFLD), has increased dramatically, thereby causing great public health and economic burden worldwide [1,2]. As a consequence of the pandemic spread of obesity, the global prevalence of NAFLD is approximately 25%, making it the leadin...
To confirm direct effects of repetitive magnetic stimulation on neuronal cells with AD, an in vitro experiment was performed. This was done by incubating HT-22 cells (mouse hippocampal cell line) with Aβ42 to mimic the AD models in vitro. The stimulation protocol of rMS consisted of 40 trai...
after simply constructing animal models of diabetes, studies on microangiopathy and macroangiopathy in the same models are scant. Rodents have different lipoprotein metabolism from humans and are highly resistant to AS. C57BL/6 mice are relatively too resistant to intraperitoneal injections of STZ to...
For example, a multifunctional vaccine made from a modified lentivirus, loaded with two BC antigens, including alpha lactalbumin, and HER2, could directly target the resident DCs in preclinical models [79]. Single injections of the DC-targeted lentiviral vectors resulted in tumour self-antigen–spec...
In pancreatic cancer, antitumor activity of zolbetuximab with or without gemcitabine in preclinical models of CLDN18.2-positive pancreatic tumors prompted the initiation of a phase 2 open-label, randomized study (NCT03816163) that is assessing the efficacy and safety of zolbetuximab plus gemcitabine...
The Higuchi diffusion model is better than all kinetic models at both pHs. The reason for selecting these particular kinetic parameters is that their R2 values were close to one, indicating a solid fit to the Higuchi diffusion model for drug release. Table 3 (supplementary material) and Fig. ...
et al. Podoplanin promotes tumor growth, platelet aggregation, and venous thrombosis in murine models of ovarian cancer. J. Thromb. Haemost. 20, 104–114 (2022). Article CAS PubMed Google Scholar Shirai, T. et al. C-type lectin-like receptor 2 promotes hematogenous tumor metastasis and ...