Another factor that was important was socioeconomic status. Patients with the lowest and very low median income levels had the worst TTRs compared with patients who had very high median incomes. It is important to keep socioeconomic status in mind and ask whether that might affect warfarin contr...
Of those warfarin-treated patients who went for regular INR monitoring, 41% exhibited levels of control similar to that in randomised trials and this deteriorated by half over time. However, in patients who have already exhibited adherence with regular monitoring and good TTR, warfarin may still ...
Polymorphisms in the CYP2C9∗2 and/or CYP2C9∗3 liver enzyme genes have been associated with decreased warfarin metabolism. Warfarin is a medication used to treat blood clots such as in deep vein thrombosis or pulmonary embolus, and to prevent new clots from forming in your body which ...
may require regular monitoring of drug levels examples include: warfarin lithium digoxin phenytoin gentamicin amphotericin 5-fluoro-urocil zidovudine Therapeutic drug monitoring therapeutic window (TW) is the range of drug concentrations in which a drug is effective TW concept is refle...
Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: meta-analysis with estimates of risk and benefit. Ann. Intern. Med. 143, 241–250 (2005). CAS PubMed Google Scholar Alexander, J. H. et al. Apixaban with antiplatelet therapy after acute coronary syndrome. N....
Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atr... Background-In the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial, apixaban compared with...
(Fig.1) [116]. Moreover, the FDA-approved anticoagulant drug warfarin, a small-molecule inhibitor of VKORC1L1, suppresses tumor growth by inducing ferroptotic cell death in vivo, indicating that warfarin may be a potential anticancer drug, especially for cancer patients with high VKORC1L1 ...
Warfarin is a drug with a narrow therapeutic index, meaning a specific blood level of the medication must be achieved for it to be effective yet not toxic to the patient. Medication Errors: Following the Script Finally, development of newer drugs offering similar activity against both enzyme targ...
Warfarin treatment in patients with atrial fibrillation: Observing outcomes associated with varying levels of INR control We aimed to determine the level of INR control associated with reduced stroke and mortality. The study used a retrospective cohort design using linked inpa... CL Morgan,P Mcewan,...
Osteonecrosis of the femoral head (ONFH) is a multifactorial disease leading to severely limited function. By far, the etiology and pathogenesis of ONFH are not fully understood, and surgery is the only effective way to treat ONFH. This study aims to ide