We report the case of a pediatric patient having an inability to achieve a therapeutic trough level for tacrolimus after conversion from brand name to the generic formulation.Case presentation: A 17-month-old male patient diagnosed with T-cell acute lymphoblasticleukemia underwent allogeneic bone ...
there is wide variability in clinical response to treatment among individuals. Therapeutic drug monitoring (TDM) has been proposed to optimize treatment; however, some patients still experience
CONCLUSION: Four to eight μg·L -1 is a suitable level for sirolimus concentration in Chinese kidney transplantation recipient patients. Regular drug monitoring and reasonably dose modulation may increase the validity and security of sirolimus application. 展开 关键词: kidney transplantation ...
Tacrolimus (TAC) has been shown to improve remission from proteinuria in patients with refractory IgA nephropathy (IgAN); however, the efficacy and safety of TAC in such patients have not been fully explored. Therefore, the present study was conducted to evaluate the tolerance to and efficacy of...
(Fig. 3). As for mastcell infiltrationinto thedermis, the number of mast cells was significantly lower in the FTY720 group than in the ointment base group. In addition, the number of mast cells was comparable in the FTY720 group and in mice without symptoms. The tacrolimus and betamethasone...
(i.e., tacrolimus), antibiotics (i.e.,vancomycin, gentamicin) and other medications have found strong correlations between drug concentrations in the blood/serum and the ISF (Ranamukhaarachchi et al., 2016). Due to the low amount of interstitial fluid in the skin (about 20nL/mm2in...
In a rat model with sciatic nerve transection, tacrolimus (4 mg/kg per day) for the period of 0, 2, 4 and 6 weeks significantly increased the average axon diameter, myelinated nerve fiber density and myelin sheath thickness [163]. After sciatic nerve injury, intragastric administration of ...
(patients with irregular nutritional intake can experience refeeding syndrome), bilirubin, total protein, albumin, and liver function tests. Oxygen saturation should be noted and may be combined with a blood gas to assess for hypoxemia and hypercapnia. Serum ammonia level should be sent, especially ...
On the other hand, it is also necessary to suppress the immune response for the therapeutic purposes such as organ and tissue transplantation, allergy, and the autoimmune disease. The fungal metabolites cyclosporin A (CsA) and tacrolimus (FK506) are the most potent immunosuppressive drugs available...
Previous studies have demonstrated dysbiosis induced by various immunosuppressants, including GC, mycophenolate mofetil, tacrolimus, and azathioprine32,33,34, suggesting that these drugs may have impacted the gut microbiota. Additionally, many patients treated with high-dose GC received proton pump inhibito...