Blockade of the thoracic sympathetic chain is a useful diagnostic and therapeutic procedure for identifying segmental nociceptive pathways, which may be causing pain due to inflammatory, infectious (herpes zoster), or structuralpathology. Celiac plexus block should be performed by a skilled ...
Figure 2. Changes in histone post-translational modifications (PTMs) associated with pain processing in preclinical models. In vivo pain models include scalding-type burn injury, orofacial or intraplantar injections (complete Freund’s adjuvant, formalin, carrageenan, or capsaicin), spinal nerve ligatio...
Management and control of pain sensation is a matter of great clinical interest. Drugs like aspirin and nonsteroidal anti-inflammatory drugs (NSAIDS) exert their antinociceptive effects by inhibiting cyclooxygenases (COX), but their side effects such as gastrointestinal bleeding and ulceration make th...
Arthrocentesis and joint injections are commonly performed for both diagnostic and therapeutic indications. Because of safety concerns, there is often relu... E Reno - 《Journal of Emergency Medicine》 被引量: 36发表: 2012年 Intra-articular injection of high molecular weight hyaluronan after arthro...
Evidence-Based Knee Injections for the Management of Arthritis The evidence supports the use of intraarticular corticosteroid injections for rheumatoid arthritis (1A+ Level), osteoarthritis (1A+ Level), and juvenile ... OT Cheng,S Dmitri,V Bruce,... - 《Pain Medicine》 被引量: 108发表: 2012...
Antiperspirants are regarded as the first-line therapy for primary focal HH and can provide significant benefit. Iontophoresis is considered to be the primary remedy for palmar and plantar HH. Botulinum toxin (BTX) injections are administered at the dermal-subcutaneous junction and serve as a safe...
Administration of two tail vein injections of exosomes (200 μg/kg/dose suspended in 0.2 ml PBS) markedly improved the pancreatic function and histology compared to CP group. Moreover, exosomes prominently mitigated the increase in amylase, lipase, tumor necrosis factor-α (TNF-α), transforming...
In another phase II clinical trial (NCT00973141), patients with knee or hip OA were randomized to receive subcutaneous injections of placebo or various doses of fulranumab. Knee and hip pain, as assessed by the WOMAC score, were effectively alleviated by fulranumab administration (3 mg every...
ADDRESSING THE BLOOD–BRAIN BARRIER With few exceptions, small molecules have been the mainstay for the treatment of psychiatric and neurological disorders as well as in pain management. In addition to the REVIEW Nondrugable protein interaction targets EB De Souza et al ... 149 G C GCG ...
With few exceptions, small molecules have been the mainstay for the treatment of psychiatric and neurological disorders as well as in pain management. In addition to the obvious benefits of oral administration that are ideal for treatment of chronic CNS conditions, small molecules (with appropriate ...