Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Thomas W. Kensler Department of Pharmacology and Molecular Sciences and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA Albena T. Dinkova-Kostova Corresponding author Correspond...
To determine if fisetin-mediated clearance of senescent cells impacts the health or lifespan of mice, WT f1 C57BL/6:FVB mice were fed a diet containing 500 ppm fisetin beginning at 85 wks of age, roughly equivalent to age 75 years in humans. This resulted in an extensi...
Seattle,WA. Bellevue Massage School –Center for Healing Arts Transcript for 513 Hour Licensing Program Equivalent for Transfer Students (U.S. Domestic Diploma) 2017 NCBTMB 617162-12 Certified 2012 Board Certification: 1000+hrs 2017 John F Barnes Myofascial Release Seminars: MFR 1, 2 & Unwi...
Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Paul D. Lampe Corresponding author Correspondence to Dale W. Laird. Ethics declarations Competing interests P.D.L. is a non-paid member of the scientific advisory board of FirstString Research and has been gra...
Funding: This work was supported by the National Institutes of Health [grant numbers xxxx, yyyy]; the Bill & Melinda Gates Foundation, Seattle, WA [grant number zzzz]; and the United States Institutes of Peace [grant number aaaa]. It is not necessary to include detailed descriptions on the...
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The tumor was minced and placed into a conical containing DMEM with 10% collagenase/hyaluronidase (10× Collagenase/Hyaluronidase in DMEM, STEMCELL Technologies, Seattle, WA) and 2% penicillin-streptomycin for 18 hours on a shaker plate in 37 °C. The digested tumor was then filtered ...
Department of Medicine, VAPSHCS, University of Washington, Seattle, WA, 98195, USA Yu Sun Contributions Y.S. conceived this study, designed the experiments, and supervised the project. F.C. performed most of the biological experiments. Q.L., D.F., and D.Z. acquired and analyzed clinical...
Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide an
The tumor microenvironment (TME) represents a milieu enabling cancer cells to develop malignant properties, while concerted interactions between cancer and stromal cells frequently shape an “activated/reprogramed” niche to accelerate pathological progr