The present study compares the effects of systemic pretraining trial injections of a cholinesterase inhibitor, tetrahydroaminoacridine (THA, 1, 3 and 5 mg/kg, i.p.) and nicotine (0.03, 0.1 and 0.3 mg/kg, i.p.) on spatial navigation water maze (WM) and passive avoidance (step-through ...
They also suggest therapeutic uses of nicotine. Like any drug, nicotine has adverse effects as well, such as convulsant actions and cardiovascular effects. Also, like a variety of therapeutic drugs from caffeine to codeine, nicotine has the adverse potential to become habit forming or addictive. ...
Villablanca ((1998) "Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro," J. Appl. Physiol. 84:2089-98) studied the effects of nicotine on endothelial DNA synthesis, DNA repair, proliferation, and cytoxicity using cultures of bovine pulmonary artery endothelia...
We used patch-clamp electrophysiology to assess the effects of varenicline on native α3β4* nAChRs (asterisk denotes the possible presence of other subunits) expressed in human adrenal chromaffin cells and compared its effects to those of nicotine. Varenicline and nicotine activated α3β4* nAChRs...
It was shown recently that a transdermal nicotine patch reliefs the symptoms in patients suffering from mild cognitive impairment. In Alzheimer's disease an alpha7-selective agonist has been found to have positive effects on...会议名称: 17th Congress of Drug Research ...
Chronic nicotine inhibits the therapeutic effects of gemcitabine on pancreatic cancer in vitro and in mouse xenografts. Eur. J. Cancer 49 (5), 1152-1158.Banerjee J, Al-Wadei HA, Schuller HM (2013) Chronic nicotine inhibits the therapeutic effects of gemcitabine on pancreatic cancer in ...
Nicotine enhances attentional and working memory aspects of executive function in the prefrontal cortex (PFC) where dopamine plays a major role. Here, we h... PD Livingstone,J Srinivasan,JN Kew,... - 《European Journal of Neuroscience》 被引量: 155发表: 2010年 Potentiation of 7 - containing...
Both the cocaine and nicotine addiction immunotherapies have reduced 'relapse' to drug use in animal model systems. To date, the active cocaine vaccine has few side effects and induces considerable antibody titers after active immunization in humans. Studies with the monoclonal phencyclidine ...
The effects of nicotine on gene expression in the brain have been documented [157, 158]. Recently, there has also been a focus on identifying potential nicotine-induced epigenetic alterations [159]. For example, chronic nicotine has been reported to enhance cocaine-induced synaptic plasticity by ...
Eucalyptol has been shown to have a variety of cardiovascular benefits. In chronic nicotine-induced hypertension, it decreases plasma levels of MMP-9 and TIMP-1 markedly, suggesting its potential to mitigate cardiovascular complications (Murad2023). Eucalyptol also enhances renal function and prevents ...