Prediction of therapeutic effects of LSD1 inhibitors based on insm1 expressionA method of predicting the therapeutic effect of chemotherapy using an antitumor agent containing an LSD1 inhibitor in a cancer patient, based on the expression level of INSM1 in a sample containing tumor cells collected ...
1953 1954 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1970 LSD's psychoactive effects discovered by Albert Hofmann (16th and 19th April) Werner Stoll publishes first paper on psychological effects of LSD in humans First English language publication on LSD ACNP Founding president ...
Drugs that modify the epigenome are powerful tools for treating cancer, but these drugs often have pleiotropic effects, and identifying patients who will benefit from them remains a major clinical challenge. Here we show that medulloblastomas driven by the transcription factor Gfi1 are exquisitely ...
Psychedelic therapies can engender enduring improvements in psychological well-being. However, relatively little is known about the psychological mechanisms through which the salutary effects of psychedelics emerge. Through integrating extant research on psychedelics with contemporary existential psychology, we pr...
Chapter Fifteen - Effects of MDMA on the Human Nervous System. In: Madras B, Kuhar M, editors. The Effects of Drug Abuse on the Human Nervous System [Internet]. Boston: Academic Press; 2014 [cited 2023 Dec 22]. pp. 475–97. https://www.sciencedirect.com/science/article/pii/B...
Recent clinical and preclinical evidence suggests that psychedelics and entactogens may produce both rapid and sustained therapeutic effects across several indications. Currently, there is a disconnect between how these compounds are used in the clinic and how they are studied in preclinical species, wh...
Numerous studies have explored the potential of EVs and exosomes as drug delivery vehicles capable of crossing or bypassing the BBB [15, 16]. Importantly, EVs can be engineered to enhance targeting efficacy and therapeutic effects using genetically modified cells as producing sources, in which the ...
A systematic review of the effects of novel psychoactive substances 'legal highs' on people with severe mental illness Introduction: Novel psychoactive substances (NPS) are synthetic substances that have been developed to produce altered states of consciousness and percepti... R Gray,D Bressington,E...
allowing for targeted effects even before the occurrence of global suppression of transcriptional activity [20,21]. This unique dependency of the SE-driven transcriptional program has provided new therapeutic targets for the treatment of cancer metastasis. In this review, we describe the formation, bio...
such as opioids and non-steroidal anti-inflammatory drugs, are frequently linked to adverse effects, including dependency and gastrointestinal issues, and often offer limited long-term relief. This review explores the potential of psychedelics, including psilocybin, LSD, and ketamine, as alternative the...