(redirected fromTherapeutic dose) Thesaurus Medical Encyclopedia Related to Therapeutic dose:Toxic Dose therapeutic index n. The ratio between the toxic dose and the therapeutic dose of a drug, used as a measure of the relative safety of the drug for a particular treatment. ...
After single 1 mg oral doses in humans, typical pharmacokinetic variables for alprazolam are: a peak plasma concentration 12 to 22 micrograms/L occurring 0.7 to 1.8h postdose, a volume of distribution of 0.8 to 1.3 L/kg, elimination half-life of 9 to 16h and clearance of 0.7 to 1.5 ...
To date, selective serotonin reuptake inhibitors (SSRIs; e.g., fluoxetines, sertralines) and other psychotropic active ingredients (e.g., alprazolam) are considered as most effective for symptomatic treatment of PMDD. A treatment with these compounds can cause serious side effects; in addition,...
FIG. 48: Dissolution profiles for alprazolam in 900 mL 0.0033N HCl at 30 rpm. FIG. 49: Dissolution profiles for alprazolam in 900 mL 0.0033N HCl at 0 rpm. FIG. 50: Dissolution profiles for sildenafil citrate in 900 mL 0.0033N HCl at 30 rpm. FIG. 51: Dissolution profiles for sildenafil...
Abecarnil and alprazolam in humans: behavioral, subjective and reinforcing effects. J Pharmacol Exp Ther 272: 570–580. CAS PubMed Google Scholar Nicholson KL, Balster RL (2001). GHB: a new and novel drug of abuse. Drug Alcohol Depend 63: 1–22. Article CAS Google Scholar Poldrugo ...
Anxiety is a widespread psychological disorder affecting both humans and animals. It is a typical stress reaction; however, its longer persistence can cause severe health disorders affecting the day-to-day life activities of individuals. An intriguing facet of the anxiety-related disorder can be addr...
Demographic and drug disposition data, consisting of two blood samples collected at a random time during two different dose intervals, was prospectively collected for 94 psychiatric inpatients (mean age, 48 +/- 13 years) receiving alprazolam. Mixed-effect modeling was used to estimate population ...
[303]. Sleep–wake cycles can be normalized in transgenic R6/2 animals by administering alprazolam and modafinil, which are sleep- and wake-promoting agents, respectively [304]. Interestingly, the cognitive function of HD mice improves not only after promoting regular sleep but also after ...
Examples of the above-mentioned other drug include opioid receptor agonists such as morphine and tramadol; antidepressants such as amitriptyline, duloxetine and milnacipran; antianxiety agents such as alprazolam; anticonvulsants such as carbamazepine; local anesthetics such as lidocaine; sympathetic agents ...
After that, a Combi Gel Alprazolam containing 1,0% w/w of Alprazolam was compared in an in vitro study against Combi Gel NETA already described in order to theoretically evaluate the feasibility of the Alprazolam gel. Finally, a bioavailability study was performed. A) In Vitro Results: ...