In addition, we highlight contemporary areas of research, including poly(ADP-ribose) polymerase inhibitors, KRAS-targeted therapies and immunotherapies. Finally, we discuss the future of pancreatic cancer research and areas for improvement in the next decade.doi:10.1038/s41575-023-00840-wZ. Ian HuEileen M. O'ReillyNature Reviews Gastroenterology & Hepatology
Therapeutic developments in pancreatic cancerAuthor(s): Z. Ian Hu , Eileen M. O’Reilly Publication date (Electronic): October 05 2023 Journal: Nature Reviews Gastroenterology & Hepatology Publisher: Springer Science and Business Media LLC
l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp metabolism in disorders ranging from cancer to neurodegenerative disease have sti
Increased SRC activity is observed in pancreatic cancer stem cells [87], and is linked to ligand/receptor signaling pathways commonly implicated in tumor progression [88,89,90]. Accordingly, therapeutic inhibition of SRC reduces pancreatic cancer stem cell abundance, as well as their colony forming ...
As a highly hard to detect and challenging to treat, pancreatic cancer (PC) is among the most lethal cancer type, ranking seventh in the leading cause of global cancer-related deaths but expected to become the second most common cause of cancer-related death in 2040 [1,2]. Additionally, ...
” he says. A therapeutic vaccine aims to target cancer cells and stimulate a patient’s immune system to strengthen its own defenses. Personalized vaccines appear poised to become an integral part of our cancer-fighting arsenal. Here’s a look at recent developments and challenges in this ...
This very small population of Cancer Stem Cells (CSC) comprises tumor initiating cells responsible for cancer recurrence, drug resistance and metastasis. Conventional treatments such as chemotherapy, radiotherapy and surgery, in addition to being potentially toxic and non-specific, may paradoxically ...
cells [80]. In pancreatic cancer, USP8 inhibits the ubiquitination-regulated proteasome degradation pathway by positively interacting with PD-L1 and upregulating its expression [81]. USP7 mediates the ubiquitination of PD-L1 and inhibits its degradation [82]. Additionally, UCHL1 promotes PD-L1 ...
[232,233,234,235]. The enterotoxin generated byClostridium perfringenspossesses anti-cancer properties as well. It binds to the overexpressed claudin-4 receptor on pancreatic cancer cells, causing dose-dependent acute toxicity [236,237]. Produced by pathogenicE. coli, verotoxin 1 (VT-1), also ...
In pancreatic cancer, the EGF pathway is often hyperactivated, which potentiates the tumour cell migration and metastasis of this highly aggressive disease. EGF stimulates pancreatic tumour cell migration on vitronectinin vitr o92,93,94and metastasisin vivo93,94and these effects require integrin αv...