nano-sized extracellular vesicles (EVs) with a lipid bilayer and a membrane structure, are naturally released by various cell types. They play an essential role in intercellular communication by transferring bioactive lipids, proteins, and nucleic acids, such as mRNAs and miRNAs, ...
In the context of the germinal center structure described earlier, communication between CD4+ T cells and B cells leads to the induction of enzyme AID.30 AID causes the deamination of cytidine, converting it to uracil in the DNA encoding the antigen receptor. The DNA repair pathway then ...
Exosomes Exosomes are vesicles secreted by a range of cell types, such as T cells and cancer cells, carrying diverse molecules such as circRNAs and playing a crucial role in intercellular communication. Characterized by a lipid bilayer membrane with embedded signal receptors, exosomes isolated from c...
Fabrication of nanostructured lipid carriers (NLC)-based gels from microemulsion template for delivery through skin Pharmaceutical Nanotechnology (2019), pp. 279-292 Basic Protocols CrossrefView in ScopusGoogle Scholar [125] Jain K., Sood S., Gowthamarajan K. Optimization of artemether-loaded NLC ...
(e.g., enhancers, and the promoter. The formation of chromatin loops before the recruitment of the activators facilitates the communication between the promoters and enhancers.60The transcriptional co-activators have also been reported to play significant role in this process. The transcriptional co-...
The communication between cancer cells and the ECM activates several vital pathways related to mechanotransduction. Therefore, a comprehensive understanding of the dysregulation of the ECM in the TME would contribute to the discovery of promising therapeutic targets for cancer treatment. In the present ...
WaaA and wbpH. The earliest genome screening study reported about 300 essential protein targets forP. aeruginosaas short communication (Sakharkar et al.2004). This approach adopted reductive screening ofP. aeruginosagenome and focused on the essential protein which could be exploited as therapeutic ta...
As described above (seeStructure of PrPTSE), the evidence for packaging of prion protein in the EVs provides a novel mechanism of prion-induced intercellular communication. In a recent study, EVs derived from the brain demonstrated the presence of enriched prion protein which was further increased...
contact with cardiomyocytes is also necessary for the secretory function of VECs.324These data suggest that dysfunction in VEC-cardiomyocyte communication will negatively affect myocardial physiology and predispose patients to maladaptive remodeling and even the progression of chronic heart failure. Unfortunatel...
To see if miR-181 and miR-324 play a role in endothelial-to-smooth muscle cell communication, human pulmonary artery smooth muscle cells (HPASMCs) were co-cultured with KLF2-overexpressing HPAECs in Transwell dishes. The two cell types were separated by a porous membrane (Fig. 4a), which ...