Envi- ronmental factors such as prenatal infection and hypoxia, stress, smoking and cannabis use, when interacting with risk genes, can also contribute to schizophrenia[15, 16]. Dysfunc- tional GABA interneuron activity can disrupt the excitatory/ inhibitory (E/I) balance in the cortex[17], ...
They can prevent the symptoms caused by withdrawal from tobacco, from alcohol and from various substances that induce a dependency, such as cocaine, LSD, cannabis and benzodiazepines. It is moreover known that activation of the vascular nicotinic receptors stimulates the proliferation of endothelial ce...
Cannabis plants accumulate phytocannabinoids in glandular trichomes, which are distributed throughout the above-ground parts of the plant, with the highest concentrations found on female flowers (inflorescence) [104]. The harvested inflorescence is then given to dry and in this form can be used for...
However, its superiority compared to other treatment modalities is not unambiguously confirmed yet; therefore, well-organized, placebo-controlled double-blind multicenter clinical trials with large sample sizes are necessary in order to find the most efficient way of using cannabis-based therapies [379...
to two cannabinoid receptor ligands (JWH-133 and Cannabixir®Medium Flos—an EU GMP-certified batch of a dried inflorescence ofCannabis sativaL. with 15.6% THC and <1% CBD) on recognition memory, as well as their influence on brain metabolism and modulation of the expanded endocannabinoid sys...
Therapeutic drug monitoring of blood levels of cannabinoids is crucial for optimizing the medical cannabis therapy, and the use of microsampling devices could facilitate the widespread adoption of this clinical practice, as well as simplify the sampling in patients who are not compliant with veni...
About 96 million individuals have already used drugs of abuse in the European Union, cannabis being the most used (27.4%), followed by cocaine (5.4%) and then ecstasy (4.1%) and amphetamines (3.7%) [1]. In recent years, a trend of new psychoactive substance (NPS) consumption has been ...