Envi- ronmental factors such as prenatal infection and hypoxia, stress, smoking and cannabis use, when interacting with risk genes, can also contribute to schizophrenia[15, 16]. Dysfunc- tional GABA interneuron activity can disrupt the excitatory/ inhibitory (E/I) balance in the cortex[17], ...
They can prevent the symptoms caused by withdrawal from tobacco, from alcohol and from various substances that induce a dependency, such as cocaine, LSD, cannabis and benzodiazepines. It is moreover known that activation of the vascular nicotinic receptors stimulates the proliferation of endothelial ce...
Cannabinoids called phytocannabinoids originate from plants, including Cannabis sativa (hemp), and have potent therapeutic potential in treating various medical conditions [1]. Hemp has been used around the world as a source of food and textile fiber since ancient times, with further recognition of ...
To date, more than 500 biologically active components were identified in the plants of the Cannabis genus, among which more than 100 were classified as pCBs. Moreover, as mentioned above, several other plants were already shown to produce molecules with cannabinoid activity [30,32,47,52]. It...
Therapeutic drug monitoring of blood levels of cannabinoids is crucial for optimizing the medical cannabis therapy, and the use of microsampling devices could facilitate the widespread adoption of this clinical practice, as well as simplify the sampling in patients who are not compliant with veni...
About 96 million individuals have already used drugs of abuse in the European Union, cannabis being the most used (27.4%), followed by cocaine (5.4%) and then ecstasy (4.1%) and amphetamines (3.7%) [1]. In recent years, a trend of new psychoactive substance (NPS) consumption has been ...