Over multiple decades, researchers have identified and engineered several classes of delivery vehicles that can overcome these complex molecular obstacles to intracellular delivery. Current state-of-the-art delivery systems, including viral vectors, LNPs, and VLPs, can satisfy these key criteria for effi...
Furthermore, anti-p40 (IL-12/IL-23) antibodies have shown efficacy whether administered before or after onset of disease in a relatively new Callithrix jacchus (nonhuman primate marmoset) EAE model ('tHart et al, 2008) and have been localized to lesions in the brain (Brok et al, 2002)....
and aptamers represent new classes of drugs to inhibit ‘nondrugable’ targets, including the emerging class of protein–protein interaction targets. They represent excellent tools to validate targets by knocking out gene expression at the level of mRNA (antisense, RNAi, and siRNA) or protein (anti...
Hypertension is a global public health issue and the leading cause of premature death in humans. Despite more than a century of research, hypertension remains difficult to cure due to its complex mechanisms involving multiple interactive factors and our
In addition to gene-level regulation by EMT-TFs, RNA-level regulation contributes to EMT mechanisms. In particular, non-coding RNAs known as microRNAs (miRNAs) are known for their either positive or negative interaction with EMT. The most famous two classes of miRNA known in EMT research are ...
While PAX6 is the major gene for congenital aniridia, in rare cases aniridia may result from variants in the ITPR1 gene causing the Gillespie syndrome (Gerber et al., 2016; McEntagart et al., 2016). Also, a single aniridia pedigree has been shown to have a missense mutation in TRIM44...
EZH2 depletion or inhibition leads to a near-total loss of H3K27me2/3 marks [31,32]. In contrast, EZH1 shows predominant expression in non-mitotic cells of somatic tissue, while EZH2 is primarily expressed in proliferating cells. The role of EZH2 is critical in the regulation of diverse ...
(Fig.6). As is the case with the PCA results, there exists an incomplete separation between the hemolytic and non-hemolytic classes in all three datasets. In many cases, positive and negatives peptides are near-coincident in the plots, and appear, therefore, to be physicochemically and ...
[9]. There are three classes of mammalian SWI/SNF complexes that differ in subunit composition, genome localisation, and have non-redundant functions. These are canonical BRG1/BRM-associated factor (BAF), polybromo-associated BAF (PBAF), and the more recently defined non-canonical (ncBAF), ...
While the present invention has been particularly described in terms of specific embodiments thereof, it will be understood in view of the present disclosure that numerous variations upon the invention are now enabled to those skilled in the art, which variations yet reside within the scope of the...