we for the first time report the high-quality genome of theI.robustastrain CD-56. Time-course (36 h, 72 h, and 144 h) dual RNA-Seq analysis of the infection process was performed, and many genes, including candidate effectors, were found to be associated with the progression...
We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucleus RNA sequencing, bulk-proteogenomics, spatial transcriptomics and cellular imaging. Subpopulations of tumor cells exhibited signatures of proliferation, KRAS signaling, cell stress and ...
GCAT genesT A C G GCAT Review The Present and Future of Whole Genome Sequencing (WGS) and Whole Metagenome Sequencing (WMS) for Surveillance of Antimicrobial Resistant Microorganisms and Antimicrobial Resistance Genes across the Food Chain Elena A. Oniciuc 1,†, Eleni Likotrafiti 2,†, ...
Whole-genome studies in yeast revealed different effects of Puf3 deletion on mRNA abundance, translation efficiency, and mitochondrial proteome abundance, highlighting its complex regulatory role [26,34,35]. Hence, to date, there is no unequivocal evidence that Puf3-mediated mRNA-localization is a ...
In a very short period, scientists at CDC successfully developed a number of real-time PCR assays for the detection of agents of bioterrorism, and these assays are now available at many of the LRN laboratories. Therefore molecular tools have improved the initial diagnosis of emerging and re...
we selected 1050 strains for whole-genome sequencing. Some isolates came from the same participant; in such cases, the isolates were always from different species. Our objective was to sequence at least one genome for each species identified by matrix-assisted laser desorption/ionization-time of ...
“cellular process”, “leukocyte aggregation”, and “regulation of prostaglandin biosynthetic process” were enriched in the cell fate 2 node; and “regulation of inflammatory response”, “regulation of macrophage activation”, and “regulation of leukocyte activation” were enriched in the cell ...
In the early stage of the pandemic, we mobilized all resources possible to meet the pressing needs of Wuhan and the whole country, sourcing, buying and receiving all kinds of medical supplies from around the world to address the urgent demand at home. ...
A major part of the transcriptome complexity is attributed to multiple types of DNA or RNA fusion events, which take place within a gene such as alternative splicing or between different genes such as DNA rearrangement and trans-splicing. In the present
Senescent cells undergo substantial changes in three-dimensional chromatin organization globally, as evidenced by the combination of whole-genome chromosome conformation capture (Hi-C), fluorescence in situ hybridization, and in silico modeling.277 Among them, lamin A/C represents an epigenetic regulator...