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animalis 7_1). Bacterial–human coculture lasted 24 h before the devices were opened and supernatants and cells were collected for downstream analysis (RNA, DNA, proteins, extracellular metabolites). Control devices with bacterial or human cell monocultures were run in parallel. RNA-seq...
We then applied the strategy outlined above to assess key longevity interventions in animal models for their effects on aging (slowing aging rate vs. age-independent effects). Major insights into longevity-associated pathways have predominantly derived from lifespan studies of genetically modified organis...
In order to adapt to a new niche, the animal needs to have access to its resources over a long period of time. This long-term availability is therefore another key feature of the paleo-synanthropic niche. When stable isotopes are used to define trophic niches, this is often done with δ...
Melgert BN, Ray A, Hylkema MN, Timens W, Postma DS: Are there reasons why adult asthma is more common in females? Curr Allergy Asthma Rep 2007,7(2):143–50. Article CAS PubMed Google Scholar MacGregor JI, Jordan VC: Basic guide to the mechanisms of antiestrogen action. Pharmacol Re...
multiformis and C. limacisporum. The distribution of ECM adhesion and cell-cell adhesion molecular components suggests the early emergence of an animal-like ECM in the last common ancestor of pluriformeans, filastereans, choanoflagellates, and metazoans and indicates that C. owczarzaki and M....
All animal experiments should comply with ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines. Studies should be carried out in accordance with Guidance on the operation of the Animals (Scientific Procedures) Act 1986 and associated guidelines, EU Directive 2010/63 for the protection...
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1a), probably as part of the cephalic expansion that commenced around the emergence of this animal lineage (the ‘new head’ hypothesis)7. Fig. 1: Adult brain atlas overview. a, Top: phylogenetic tree displaying the main vertebrate lineages and their approximate brain anatomies; the blue bar...