Post-translational modification of proteins by ubiquitin and ubiquitin-like modifiers, such as SUMO, are key events in protein homeostasis or DNA damage response. Smc5/6 is a nuclear multi-subunit complex that participates in the recombinational DNA repa
The two stimulus types elicited distinct neural pathways: while sweetener stimulated purinergic neurotransmission, sugar stimulated glutamatergic neurotransmission. To probe the contribution of these cells to behavior, we developed optogenetics for the gut lumen by engineering a flexible fiberoptic. We showed...
Two different doses were utilized to determine the mechanism by which T-A-Ls alleviate CDDP induced AKI through the inhibition of oxidative stress and inflammation. Histopathological Analysis Hematoxylin and Eosin (H&E) Staining At the end of the experiment, mice were sacrificed by cervical ...
Numerous studies have demonstrated that microgravity dramatically affects the physiological functions of human body inducing impairments in cardiovascular, musculoskeletal, endocrine and immune systems[1]. Besides, it was also suggested that cerebral malfunction occurred during or after spaceflight. For example...
These data demonstrate that, as in the case of CO delivery, Mn–HYCOs are more potent than Ru–HYCOs in activating the Nrf2/HO-1 axis in the two types of human cells tested. Because HYCO-11 was the only compound incapable of either releasing CO or stimulating HO-1 protein expression, ...
Recent years have witnessed the emergence of several viruses and other pathogens. Some of these infectious diseases have spread globally, resulting in pand
stresses affect rice growth or have investigated the mechanism of rice seedling damage from various perspectives, such as physiological indicators, transcriptomics, and proteomics [26,27]; however, less attention has been given to the compensatory growth of rice seedlings after stress. Investigating the...
However, the lack of a lipid bilayer and the limitation of the size of micelles may not preserve the membrane proteins’ structural and dynamic integrities under physiological conditions [1], [3], [4], [5]. To better maintain the structural integrity of membrane proteins, several classes of...
Since their discovery, they have been found to play crucial roles in many physiological and pathological processes, and the last 10 years have witnessed the explosion of studies on exosomes and other EVs. They carry large amounts of materials, including proteins, lipids, and miRNA/mRNA/DNA, ...
physiological levels of arginine. Untargeted metabolomics also revealed that spheroids grown in Plasmax were metabolically more similar to breast tumours than spheroids grown in classical media16. Additionally, urate, the end product of nucleotide catabolism, is a metabolite that is present in human circ...