Inhibitory effect of acetylcorynoline on the activation of the IKK/NF-κB and MAPK signaling pathways in LPS-stimulated mBM-DCs.RuHuei, Fu
To achieve these research objectives, the study uses the AHP, a widely used method to solving complex multi-criteria problems, to prioritise KPIs that positively contribute to managing the circular transition. The study consists of three key phases. The first phase begins with a comprehensive ...
To methodically compile and evaluate pertinent research studies, a structured three-stage search and screening approach was implemented using the Scopus database [23]. Initially, a search was conducted with four distinct keywords: “Micro Gas Turbine”, “Economy”, “Techno Economy”, and “Techno...
Exploitation of phage display for the development of anti-cancer agents targeting fibroblast growth factor signaling pathways: New strategies to tackle an old challenge - ScienceDirectBehzad Jafari a bMaryam Hamzeh-Mivehroud a cMichael B. Morris d...
In cancer cells, MeCP2 activates the MAPK and PI3K signalling pathways, mimicking the action of RAS in malignancies [170]. In addition to its methyl-CpG binding domain (MBD), MeCP2 has three AT-hooks (AT-hook 1, aa 184–195; AT-hook 2, aa 264–273; AT-hook 3, aa 341–364)...
The BCR-ABL1 protein has constitutive tyrosine kinase activity, which interferes with the activation of oncogenic cytoplasmic signaling molecules or pathways [144]. While the disease is typically diagnosed in the chronic phase, in 5% to 10% of cases, it may transform to an accelerated or blast ...
3.2. HA Synthesis in the Human Body In the human body, HA is synthesized as a free linear polymer by three transmembrane glycosyltransferase isoenzymes named hyaluronan synthases, HAS: HAS1, HAS2 and HAS3, whose catalytic sites are located on the inner face of the plasma membrane. HA ...
Odd-chain fatty acids undergo β-oxidation in the same metabolic pathways as even-chain fatty acids. However, the final spiral of β-oxidation yields one acetyl-CoA molecule and one propionyl CoA molecule. This three-carbon molecule undergoes enzymatic conversion to succinyl CoA, thus bridging the...
molecules Article Acenocoumarol Exerts Anti-Inflammatory Activity via the Suppression of NF-κB and MAPK Pathways in RAW 264.7 Cells Hyun-Ju Han and Chang-Gu Hyun * Jeju Inside Agency and Cosmetic Science Center, Department of Chemistry and Cosmetics, Jeju National University, Jeju 63243, ...
According to PCoA (Figure 5D) and NMDS (Figure S5A), there was a significant difference among the three groups of communities (p < 0.05). Subsequent analysis based on PCoA alone revealed that (Figure S5B), consistent with the ileal results, the addition of AM significantly affected the gut...