We develop an effective theory approach to investigate the phase properties of globular proteins. Instead of interactions between individual atoms or localized interaction centers, the approach builds directly on the tertiary structure of a protein. As an example we construct the phase diagram of (apo...
Predicting the tertiary structure of protein from its primary amino acid sequence is a challenging mission for bioinformatics. In this paper we proposes a novel approach of predicting the tertiary structure of protein using the flexible neural tree (FNT) to construct a tree classification model. Two...
Modern adaptations ofmass spectrometryprovide an important alternative to the sequencing methods described above.Mass spectrometrycan provide a highly accurate measure of the molecular weight of a protein, but can also do much more. In particular, some variants of mass spectrometry can provide the sequ...
Related to Tertiary structure of proteins:Secondary structure of proteins n. The complete three-dimensional structure of all the atoms in a protein or nucleic acid, consisting of the arrangement of the secondary structure into patterns such as folds and supercoils. ...
To answer the question "How is the tertiary structure of a polypeptide related to its primary structure?", we need to understand the relationship between these two levels of protein structure. 1. Understanding Primary Structure: - The primary structure of a polypeptide refers to the linear sequenc...
The face to face stacking of two primarily antiparallel β-sheets to form a β-sandwich occurs in several globular proteins including the domains of the immunoglobulins. We have examined the tertiary structures of ten β-sandwiches to show that they form a well-defined structural class with the ...
Tertiary structure of an amyloid immunoglobulin light chain protein: a proposed model for amyloid fibril formation. An immunoglobulin light chain protein was isolated from the urine of an individual (BRE) with systemic amyloidosis. Complete amino acid sequence of the var... Schormann,J R,Murrell,....
Proceedings of the 2012 2nd International Conference on Computer and Information Application (ICCIA 2012) Predict the Tertiary Structure of Protein with Error-Correcting Output Coding and Flexible Neural Tree Yiming Chen School of Information science and Engineering, University of Jinan Jinan, PR China ...
of a stabilized protein tertiary structure that acts as an inhibitor of the interaction between the transcription factor TEAD and its co-repressor VGL4, both playing a central role in the Hippo signalling pathway. Modification of the inhibitor with a cell-penetrating entity yielded a cell-permeable...
A model is suggested for the tertiary protein structure in terms of a system of relatively straight segments interrupted by folding points between them. The latter have a special significance in the formation of a protein globule. Turns in the polypeptide chains are regarded either as a flexible ...