TSC Talks. Where I share and reflect my lived experience within the dense matrix and systemic programming. Awakening through the role of parent/caregiver of loved ones affected by Tuberous Sclerosis Complex. Observing and integrating traumas and the limi
]. In the setting of transformation, use of the term “Richter transformation” is recommended over “Richter Syndrome”. B-prolymphocytic leukaemia (B-PLL) of WHO-HAEM4R is no longer recognized in WHO-HAEM5 in view of its heterogeneous nature. Cases that have been labeled as B-PLL ...
In Thailand, the IC3 certification is widely adopted as a measure of digital literacy proficiency [7]. During the pilot phase, the IC3 certification was implemented at RMUTT as a testing standard as part of a short-term program aimed at enhancing students' digital skills. Although the ...
The canonical NF-κB pathway is activated by extracellular stimuli (pro-inflammatory cytokines, growth factors) which are recognized by membrane-bound receptors (e.g., TNF receptor superfamily; TNFR, IL-1 receptor; IL-1R and Toll-like receptor 4; TLR4) that transmit the signal into the cell ...
Arctic sea-ice extent was below the long-term average for most of the year. The September extent was0.71 million km2below the long-term mean extentand it tied for the 11th lowest monthly minimum ice extent in the satellite record.
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer associated with advanced age and immunosuppression. Over the past decade, an association has been discovered between MCC and either integration of the Merkel cell polyomavirus, which likely
When Wnt signaling is activated, β-catenin acts as a corepressor of one of the autophagy proteins, p62. In contrast, another key Wnt signaling protein, GSK3β, negatively regulates the Wnt pathway and has been shown to induce autophagy by phosphorylation of the TSC complex. This article ...
Tumor immune escape is an important strategy of tumor survival. There are many mechanisms of tumor immune escape, including immunosuppression, which has become a research hotspot in recent years. The programmed death ligand-1/programmed death-1 (PD-L1/PD
, they should not be conflated with phylogenetic networks, but recognized as a more inclusive object of study (Fig.4). Where phylogenies describe relationships, networks can describe organisations. How such organisations evolve could for example be described by identifying evolutionary stages, that is...
Valine, leucine and isoleucine are essential amino acids that share side chain structure features to which the collective term branched-chain amino acids (BCAAs) refers to. Unlike most of amino acids, only a minor fraction of the dietary BCAAs is metabolized by the liver; the largest part of...