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Cell death is currently described on the basis of three modalities associated with different morphological characteristics: apoptosis, autophagy, and necrosis [1,2]. Ferroptosis is a recently discovered form of regulated cell death (RCD) and is described as nonapoptotic, caspase-independent cell death ...
Aging, which is broadly defined as the progressive decline of physiological functions of the organism, is driven by alterations in specific molecular and cellular processes, such as genomic stability, proteostasis, mitochondria function, cellular senescence survival and intercellular communication [189]. Un...
The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associa...
The ‘liability of ageing’ can be further divided into ‘liability of senescence’ and ‘liability of obsolescence’. The ‘liability of senescence’ describes the inner change of firms due to ageing, such as rigid structures, bureaucratic ossification, organizational inertia, and over-reliance on ...
would be anticipated to arise from this squamous epithelium (3). Now, molecular determinants are revealing mechanisms of transdifferentiation in various cancers, both for cases where gross tissue metaplasia is evident and for others where it is rather more subtle, as the following examples illustrate...
More research needs to be conducted on the elderly microbiome in the context of immune senescence, co-morbidities, and infection susceptibility, but the stability of the human microbiome may decrease at either extreme of age. Long-term effects of antibiotic perturbation depend on microbiome state ...
Note that in general the total number of GO terms is greater than the number of unique contigs, as many of the contigs map to zebra finch genes with more than one associated GO term. Of the 33,574 contigs aligning with zebra finch cDNA sequences, GO terms could be extracted for 20,...
]. In the setting of transformation, use of the term “Richter transformation” is recommended over “Richter Syndrome”. B-prolymphocytic leukaemia (B-PLL) of WHO-HAEM4R is no longer recognized in WHO-HAEM5 in view of its heterogeneous nature. Cases that have been labeled as B-PLL ...
The term “ferroptosis” originated from the rescue effect of the iron chelator DFO. In the clinic, DFO, deferiprone (DFP), and deferasirox (DFX) are commonly used iron chelators.104DFO is derived fromStreptomyces pilusand is approved for managing iron overload‒related diseases such as hemoch...