multiple sclerosis n.Abbr.MS A chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord or both, interfering with the nerve pathways and causing muscular weakness, loss of coordination, and speech and visua...
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We discuss the distinct challenges that families are faced with at different stages of disease progression (emerging, diagnostic, longterm adaptation, crisis, chronic, and terminal) for one particular condition (multiple sclerosis or MS). A number of recommendations are made for supporting family ...
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease that affects the central nervous system (CNS) and is characterized by inflammation, multifocal demyelination, axonal loss, and gliosis in both the white and gray matter. MS is a complex disease with considerable clinical an...
Multiple sclerosis (MS) is a common, life-long auto-immune disease affecting 1 in 3000 individuals worldwide.1MS patients suffer from progressive, permanent damage to nerve fibers, decreasing their autonomy and compromising their quality of life. ...
Mediastinal gray zone lymphoma (MGZL) is a B-cell lymphoma with overlapping features between primary mediastinal B-cell lymphoma (PMBL) and classic Hodgkin lymphoma (CHL), especially nodular sclerosis CHL (NSCHL). This entity replaces the term “B-cell-lymphoma, unclassifiable with features interm...
In patients with multiple sclerosis, modified histones have been detected in non-lesioned white matter.15,16 The role of the epigenome in multiple sclerosis has been inferred from epidemiological studies of the effect of geographic location, month of birth, nutritional status (eg, diet and vitamin...
(IFNγ) may augment anti-tumor responses. The schematic also highlights the metabolic changes in CIML NK cells. Metabolic alterations, including the roles of glucose transporter and transferrin receptor, are emphasized for their critical contribution to the long-term persistence and recall functions of...
subtypes when there are multiple possible fusion partner genes of a biologically dominant gene (e.g.,KMT2A). Of note, the use of the term rearrangements is maintained in the classification due to its wide usage across prior editions, although it is recognized that it is more appropriate for ...
Results from the present study indicate that at transcriptomic level reduction in OXPHOS, DNA repair and inflammation-related genes is linked to better insulin sensitivity and protection against microvascular complications in persons with long-term type 1 diabetes....