Programmed cell deathSelectionUnicellular organismsIn multicellular organisms, cells are frequently programmed to die. This makes good sense: cells that fail to, or are no longer playing important roles are eliminated. From the cell's perspective, this also makes sense, since somatic cells in ...
Programmed cell death and the control of cell survival: lessons from the nervous systemPresents a neurotrophic strategy for the regulation of neuronal numbers... Raff,C Martin,Barres,... - 《Science》 被引量: 3233发表: 1993年 Control of programmed cell death by neurotransmitters and neuropeptides...
Bcl-2 and the regulation of programmed cell death. [Review]. J. Cell Biol. 124:1–6. Google Scholar S. J. Korsmeyer, J. R. Shutter, D. J. Veis, D. E. Merry, and Z. N. Oltvai (1993). Bcl-2/Bax: A rheostat that regulates an anti-oxidant pathway and cell death. [...
B7-H1 (programmed cell death ligand 1) is required for the development of multifunctional Th1 cells and immunity to primary, but not secondary, Salmonella ... McSorley SJ.B7-H1 (programmed cell deathligand 1)is required for the development of multifunctional TH1 cellsand immunity to primary,but...
Programmed necrosis: backup to and competitor with apoptosis in the immune system. Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies ... Han,Jiahuai,Zhong,... - 《Nature Immunology》 被引量:...
The data document that the killing of replicating mouse fibroblasts by etoposide represents an example of programmed cell death (apoptosis) that depends on protein synthesis. Although protein synthesis is required during the first 24 hr of exposure to etoposide, cell death is delayed until several ...
Programmed cell death caused by repeated stimulation of T cells that serves as a negative regulator of activation. Maximum tolerated dose The highest dose of treatment that does not cause intolerable side effects. Suicide switches Genetically encoded molecules included in a chimeric antigen receptor (CA...
First introduced by Dixon et al. in 2012, ferroptosis is a form of programmed cell death (PCD), a term distinct from other modes of cell death such as necrosis, apoptosis, autophagy, necroptosis, and pyroptosis, which is essential for maintaining homeostatic balance [7,8,9]. Morphologically,...
et al. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94, 739–750 (1998). Article CAS PubMed Google Scholar Nagasaka, A., Kawane, K., Yoshida, H. & Nagata, S. Apaf-1-independent programmed cell death in mouse development. Cell Death Differ. 17,...
Programmed cell death (PCD) is involved in the removal of superfluous and damaged cells in most organ systems. The induction phase of PCD or apoptosis is characterized by an extreme heterogeneity of potential PCD-triggering signal transduction pathways. During the subsequent effector phase, the ...