et al. Early antibiotic exposure is not detrimental to therapeutic effect from immunotherapy in hepatocellular carcinoma. Liver Cancer 10, 583–592 (2021). Article CAS PubMed PubMed Central Google Scholar Serpas Higbie, V. et al. Antibiotic exposure does not impact immune checkpoint blockade ...
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and treatment of a wide range of diseases. The recent success of the two highly efficacious mRNA vaccines produced by Moderna and Pfizer–BioNTech to protect against COVID-
Understanding the mechanistic effects of novel immunotherapy agents is critical to improving their successful clinical translation. These effects need to be studied in preclinical models that maintain the heterogenous tumor microenvironment (TME) and dys
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers, posing a serious public health challenge that necessitates the development of new therapeutics, therapies, and prevention methods. Among the various therapeutic approaches, interventi
7-9 Well-tolerated new therapies that can produce substantial, sustained weight loss, when used long term, are therefore needed.7,10 Subcutaneous semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist approved for the treatment of type 2 diabetes at doses of 1.0 mg or less once...
Combination olaparib plus bevacizumab treatment received approval from the Food and Drug Administration (FDA) on May 8, 2020 as a therapeutic option for patients diagnosed with HRD-positiveadvanced epithelial ovarian, fallopian tube, or primary peritoneal carcinoma that exhibited partial or complete ...
The TGF-β signaling pathway governs key cellular processes under physiologic conditions and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional cytokine that acts in a cell- and context-dependent manner as a tumor promoter
evaluate the cost-effectiveness of pembrolizumab compared with chemotherapy as second-line therapy for the treatment of locally-advanced or metastatic urothelial carcinoma at a willingness-to-pay threshold of €100 000 per quality-adjusted life year (QALY) from a Swedish health care perspective [14]...
We also observe a cluster of cancer-associated fibroblasts (CAFs) consisting almost exclusively of cells from CRCs, and a scATAC cluster of fibroblasts enriched for cells from polyps and CRCs with accessibility around some of the same genes as CAFs, which we term pre-cancer-associated fibroblasts...
known to contain stimulants such as caffeine, are consumed widely but are subject to limited regulatory oversight. Long-term and heavy consumption of coffee could result in caffeine dependence, and discontinuation may lead to withdrawal symptoms such as fatigue, difficulty concentrating, and muscle pai...