These include tumor associated macrophages (TAMs), myeloid – derived suppressor cells (MDSCs), tumor – associated neutrophils (TANs) and tumor – associated dendritic cells (TADCs)17. The immune microenvironment of gliomas mainly consists of peripherally derived macrophages18. Macrophages can ...
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Justin, Neal
The resulting reduction in the frequency of immunosuppressive TAMs may have the potential to inhibit tumor metastasis18,19,20,32. Here, we ask whether SAM engineered to express dual payloads of ClyA and FlaB might potentiate the anti-tumor activity of SAM in primary and metastatic tumor models ...
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C Volume change in each group with different treatment schedule (n = 5–8 per group). Two-way analysis of variance (ANOVA) was performed. D Kaplan–Meier survival curves of the subcutaneous tumor-bearing mice treated as indicated since the day of tumor volume reached 100–150 mm3. ...
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Some studies have found that low-dose RT modulates the polarization of TAMs to the M2 phenotype to maintain their ability to promote invasion and angiogenesis[50, 11]. Thus, the dose and schedule of RT may evoke different changes in the tumor microenvironment. In our study, we did not ...
This is particularly relevant in the context of GBM, where M2-like TAMs are found in higher percentages in their microenvironments compared to other tumor types, suggesting they play a contributory role in the immune suppressive microenvironment found in these tumors32,56. Hence, there is ...
(TAMs). A heterogeneous population of differentiated monocytes found in the microenvironment of solid tumours, mainly consisting of cells with immunosuppressive functions (also known as M2-like macrophages) as well as a minor population of cells with pro-inflammatory functions (also known as M1-like...