The adaptive immune response is a major determinant of the clinical outcome after SARS-CoV-2 infection and underpins vaccine efficacy. T cell responses develop early and correlate with protection but are relatively impaired in severe disease and are asso
T-cell immune response after mRNA SARS-CoV-2 vaccines is frequently detected also in the absence of seroconversion in patients with lymphoid malignanciesCOVID-19lymphoid malignanciesT-cell immune responseSeroconversionanti-CD20 antibodyPatients affected by lymphoid malignancies (LM) are frequently immune-...
11月29日,山东师范大学生命科学学院何洪彬教授,王洪梅教授,军事兽医研究所高玉伟研究员带领的团队,在期刊 Cellular & Molecular Immunology 发表题为 SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy 的论文。
T cells have an important role for COVID-19 outcome and maintenance of SARS-CoV-2 immunity, even in the absence of humoral immune responses1,11,12,13,14,15,16,17,18,19. Thus, the induction of SARS-CoV-2 T cell immunity is a central goal for vaccine development and of particular imp...
We evaluated here the importance of the innate immune response during SARS-CoV-2 infection and the molecular mechanism of IFN β-mediated antiviral activity against SARS-CoV-2 infection and concluded that the IFN β monotherapy as an attractive potent treatment option against SARS-CoV-2. 2. Host...
SARS-CoV-2 COVID-19 immunity antibody T cell B cell immunological memory longevity of immune response IgG neutralizing antibody Introduction The emergence and spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a pandemic with a major impact on global health. The ...
SARS-CoV-2,andsomeofwhichsubsequentlyreceivedCEmarking.However,becausethe researchanddevelopmenttimewasshort,theapprovedkitswerenotverifiedoroptimizedwith appropriatenumbersofclinicalsamples,whichmayhaveaffectedtheirLoDs.Toexamine whetherLoDisafactorcontributingtotheobservedfalse-negativeresults,weevaluatedand ...
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused millions of infections and deaths worldwide since its emergence in December 2019. As there is little or no natural immunity in the
SARS-CoV-2 infection activates the body’s immune system to fight off infection. This immune response results in the production of proteins in the blood that target the virus called antibodies. The extent and duration of this antibody response may be associated with the type of symptoms the inf...
respiratory infections; parenteral vaccines; nasal vaccines; mucosal immunity; SARS-CoV-2; B-cell peptide-based vaccine; prime-boost immunization Graphical Abstract1. Respiratory Tract Infections and Mucosal Immune Responses Respiratory infections are a leading cause of illness and mortality worldwide [1...