network meta-analysisNIHSSsymptomatic intracranial hemorrhageAlthough acute minor stroke often presents with mild symptoms, such as unilateral limb weakness, mild aphasia, dizziness, or mild cognitive impairment
Osteonecrosis of the femoral head (ONFH) is a multifactorial disease leading to severely limited function. By far, the etiology and pathogenesis of ONFH are not fully understood, and surgery is the only effective way to treat ONFH. This study aims to ide
During the development of aging, kidney yang tonifying Chinese herbs and formulas activate macrophages in the liver, enhance their function of phagocytosis of bacteria and viruses, and at the same time promote the synthesis of NO and the release of TNF-α, IL-6 and IL-1β by macrophages. ...
Rafael Amado, M.D.President, head of Global Oncology Research and Development Zai LabMedicalResearch.com: What is the background for this study?Response:Zai lab is focused on discovering and developing innovative therapies that will help address medical conditions where there are serious unmet needs...
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Cai RZ, Szoke B, Lu R, Fu D, Redding TW, Schally AV (1986) Synthesis and biological activity of highly potent octapeptide analogs of somatostatin. Proc Natl Acad Sci USA 83:1896–1900 Article PubMed CAS Google Scholar Calabuig R, Weems WA, Moody FG (1990) Choledochoduodenal flow: effe...
and the synthesis of pro-inflammatory mediators that coordinate the elimination of pathogens and infected or damaged cells. Inflammatory enzymes locally produce arachidonic acid–derived eicosanoids, such as prostaglandins (PG), leukotrienes (LT), and thromboxanes (TX), which mediate the generation of ...
Indole and coumarin are the most versatile and cogent heterocyclic scaffolds which are not only decisively used in the synthesis of various organic compounds but also play a consequence role in natural product synthesis, modulation of biofilm formation,
may be an additional cellular facilitator of SARS-CoV-2 cell entry and infectivity.27In addition, an RNA sequencing analysis shows that although immune cells do not express ACE2 or TMPRSS2, another receptor for SARS-CoV-2, a transmembrane protein of the immunoglobulin cluster of differentiation ...
Once-daily (od), low-dose aspirin (75–100 mg) is recommended to reduce the thrombotic risk of patients with essential thrombocytemia (ET). This practice is based on data extrapolated from other high-risk patients and an aspirin trial in polycythemia vera, with the assumption of similar...