Drug resistance is one of the most difficult challenges facing tuberculosis (TB) control. Drug efflux is among the mechanisms leading to drug resistance. In our previous studies, we partially characterized the ABC-type MSMEG-3762/63 efflux pump inMycobacterium smegmatis, which shares high percentage...
The main constituent of the ring polymers present in the cartwheel is the evolutionarily conserved SAS-6 protein family. SAS-6 proteins harbor a globular N-terminal head domain followed by a coiled-coil domain and an unstructured C-terminal moiety8,9. Through their coiled coil, SAS-6 proteins ...
Methane (CH4) has a strong global warming potential and the process by which it is produced (methanogenesis) is a key process underlying climate change [1]. Methanogenesis is largely constrained to a group of anaerobic methanogenic archaea that belong to the archaeal phylum Euryarchaeota, while sev...
success of Bitcoin during the last six years proved that blockchain tech- nology has real-world value. However, this technology also has a number of drawbacks that prevent it from being used as a generic platform for cryptocurrencies across the globe. One notable drawback is the concept of a...
Moreover, DTrace is safe: you can't damage the running system because DTrace has security, complete safety, and error checking at the core of its design. These features enable you to use DTrace with confidence on your running system whenever you need the facility to help investigate a ...
The Reverse Engineering Process is based on Information gathering to identify hardware and software components of the device and get the firmware and the root file system; Build an emulation environment using QEMU, Buildroot and Docker to have a debugging friendly environment where to run interesting...
In fungi, environmental pH is an important signal for development, and successful host colonization depends on homeostasis. Surprisingly, little is known regarding the role of pH in fungal-fungal interactions. Species of Trichoderma grow as soil saprobes
Fig. 10. Schematic representation of the preferred conformations of a, lactose; b, N-acetyllactosamine; and c, Galβ1,3GalNAc taken from Ahmed et al. (1990)and proposed solution conformation of d, A-tetrasaccharide taken from Abbott et al. (1988). The results of peptide sequencing describe...
Copper transporting P-type (P1B-1-) ATPases are essential for cellular homeostasis. Nonetheless, the E1-E1P-E2P-E2 states mechanism of P1B-1-ATPases remains poorly understood. In particular, the role of the intrinsic metal binding domains (MBDs) is enigm
Enzymes are involved in various types of biological processes. In many cases, they are part of multi-component machineries where enzymes are localized in close proximity to each-other. In such situations, it is still not clear whether inter-enzyme spacin