We report a crystal structure refined to 3.6 angstrom resolution of the ribosome trapped with EF-G in the posttranslocational state using the antibiotic fusidic acid. Fusidic acid traps EF-G in a conformation intermediate between the guanosine triphosphate and guanosine diphosphate forms. The ...
The structure and function of ribosomes Ribosomes are essential components of cells that assist in the process of protein synthesis. They are found in both prokaryotic and eukaryotic cells and play a crucial role in maintaining the proper functioning of cells. This article will discuss the ...
Figure 1. Structure of the bacterial ribosome in complex with EF-Tu (PDB 5AFI [3]). Scheme of the bacterial translation cycle as reviewed in [4]. 30S: small subunit; 50S: large subunit; IF1, IF2, IF3: initiation factors; fM-tRNA: N-formylmethionine tRNA; aa-tRNA: aminoacyl tRNA;...
The ribosome has long been considered as a consistent molecular factory, with a rather passive role in the translation process. Recent findings have shifted this obsolete view, revealing a remarkably complex and multifaceted machinery whose role is to or
Y. 1974. On the structure of liver ribosomes. J. Mol. Biol . 86 :577–586.Kiselev, N. A., V. Ya. Stel’mashchuk, M. I. Lerman, and O. Yu. Abakumova, 1974 On the structure of liver ribosome...
MG Gagnon, et. al., “Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome,” Science, 335:1370-2, 2012. 4.细菌核转运蛋白 命名:霍乱弧菌富集型核背转运蛋白(vcCNT) 来自杜克大学的研究人员确定了一种可将化疗和抗病毒药物带入细胞的关键分子的结构,这一...
Ribosome recycling orchestrated by the ATP binding cassette (ABC) protein ABCE1 can be considered as the final—or the first—step within the cyclic process of protein synthesis, connecting translation termination and mRNA surveillance with re-initiation
[1], ribonuclease P (RNase P) is one of two universal ribozymes (the other is the ribosome) that are present in all living organisms. This ribonucleoprotein is generally composed of an RNA subunit, the RNase P RNA (RPR), and one or more protein subunits, the RNase P proteins (RPPs)...
ribosome Thesaurus Medical Legal Financial Encyclopedia Wikipedia ri·bo·some (rī′bə-sōm′) n. A structure composed of RNA and protein, present in large numbers in the cytoplasm of living cells and serving as the site for assembly of polypeptides encoded by messenger RNA. ...
We propose that this rRNA structure likely participates in the recruitment of ribosome onto the 5′ end of mRNA, in facilitating and modulating the initiation of translation that is unique to the trypanosomes. 展开 关键词: eukaryote translation initiation ...